紫外-可见分光光度法对去甲柔红霉素电离常数的研究  

Study of the Ionization Constant of Anticancer Drug-idabicin with UV-Vis

作　　者：彭惠琦[1] 施国跃[1] 刘敏[1] 徐继明[1] 

机构地区：[1]华东师范大学化学系,上海200062

出　　处：《华东师范大学学报（自然科学版）》2002年第4期54-57,共4页Journal of East China Normal University(Natural Science)

摘　　要：作者用紫外-可见分光光度法(UV-Vis)研究了抗癌药物-去甲柔红霉素的电离常数。配制了一系列pH值的去甲柔红霉素溶液并在去甲柔红霉素的特征波长485nm处分别测定它们的吸光度,根据吸光度的变化求得去甲柔红霉素的pKa值。该方法简单、易行,操作方便。In this paper, UV-Visible spectrometry was employed to study the ionization constant of anticancer-drug Idabicin. The standard solution of series pH value were prepared and the absorbance was measured at 485 nm which is the specific wave length of this drug. Then the ionization constant is obtained according to the change of absorbance. This way is proved to be simple, applicable and easily operated.

关 键 词：去甲柔红霉素 紫外-可见分光光度法 电离常数 抗癌药物 吸光度 蒽环类抗生素 

分 类 号：R979.14[医药卫生—药品] R927[医药卫生—药学]