甲状腺激素对慢性心力衰竭患者外周血淋巴细胞β肾上腺素能受体密度的影响  

Effects of thyroxine on density of peripheral lymphocyteβ-adrenoceptors in patients with congestive heart failure

作　　者：卢新政[1] 黄峻[1] 李新华[2] 王赤京[2] 张佩生[2] 陈永生[2] 

机构地区：[1]南京医科大学第一附属医院心内科,南京210029 [2]郑州铁路局中心医院心内科

出　　处：《临床心血管病杂志》2002年第12期628-630,共3页Journal of Clinical Cardiology

基　　金：郑州铁路局科委基金资助项目 (No.99w33)

摘　　要：目的 :探讨甲状腺激素 (TH)对慢性充血性心力衰竭 (CHF)患者外周血淋巴细胞 β肾上腺素能受体(β受体 )密度的影响。 方法 :2 8例扩张型心肌病 (DCM)及特发性心肌病 (ICM)所致的CHF患者随机分为A及B组 (各 14例 ) ,B组在A组常规抗心力衰竭治疗基础上加服左甲状腺激素钠 (优甲乐 5 0 ,L T50 ) 1个月 ,治疗前后 ,采用放射免疫法测定血清TH水平、同位素放射配基法测定外周血淋巴细胞 β受体密度 ,并与 8例正常人对照。 结果 :CHF患者淋巴细胞 β受体及血清TH密度低于对照者 ,治疗 1个月后 ,B组较A组血清TH水平明显增高 (P<0 .0 1) ,外周血淋巴细胞 β受体增加 (P <0 .0 5 ) ,外周血淋巴细胞 β受体变化与血清TH水平呈正相关。 结论 :TH增加DCM和ICM所致CHF患者血清TH水平 ,上调其外周血淋巴细胞Objective:To analyze the density of β adrenoceptors (β AR) of lymphocytes among 28 patients with congestive heart failure(CHF) and its change before and after treatment by L thyroxine (L T 50 ). Methods:28 patients with class Ⅲ or Ⅳ advanced CHF due to dilated cardiomyopathy (DCM) or ischemic cardiomyopathy (ICM) were randomly divided into group A and B. Patients in group A were conventionally treated with digitalis nitrite and diuretic, while patients in gronp B were treated in eddition to conventional drngs, with addiltional L thyroxine (L T 50 ) Before and after one month of treatment, Ficoll Hyperque liquid was used to separate peripheral lymphocytes, 125 I Pindolol radioligand banding was used to measure β AR in peripheral lymphocytes.Results:The maximal number of banding sites (βmax ) in peripheral lymphocytes and the serum TH in patients with CHF were lower than thase in conyrok, after one month TH therapy, βmax and serum TH were hirher in groap B than those in group A. Conclusion:The density of β AR of lymphocytes in patients with CHF due to ICM or DCM was lower than that in normal health people, L thyroxine administration induced a β AR up regulation in peripheral lymphocytes.

关 键 词：充血性心力衰竭 甲状腺激素 Β肾上腺素能受体 淋巴细胞 

分 类 号：R541.61[医药卫生—心血管疾病]