不同处理方法的牛心包生物力学特性测试分析  

A STUDY ON BIOMECHANICAL PROPERTIES OF BOVINE PERICARDIUM FOLLOWING DIFFERENT CHEMICAL TREATMENT

作　　者：王坚刚[1] 蒯行成[2] 胡野荣[3] 任毕乔[2] 龚光甫[3] 

机构地区：[1]首都医科大学附属安贞医院心外科,北京100029 [2]湖南大学工程力学系,长沙410012 [3]中南大学湘雅二院心胸外科,长沙410011

出　　处：《医用生物力学》2002年第4期225-230,共6页Journal of Medical Biomechanics

摘　　要：目的　探索一种理想的牛心包处理方法。方法　观察戊二醛及 2 ,3 -丁二醇改性戊二醛处理后的牛心包热挛缩温度、生物力学特性及超微结构变化。结果　鞣制后心包厚度和僵硬度增加 ,柔韧性降低。丁二醇组的弹性模量 (8.75± 1 .71 )较戊二醛组 (6.5 9± 1 .3 7) (P <0 .0 5 )更近似于正常瓣膜组织 ;且其极限拉伸强度优于戊二醛组。超微结构显示丁二醇组胶原纤维与弹性纤维结构完整 ;戊二醛组胶原纤维和弹性纤维均明显变性 ,结构模糊。结论　 2 ,3 -丁二醇改性处理后的牛心包具有更好的生物力学特性 。Objective To investigate an ideal method of treating bovine pericardial. Methods The changes of biomechanical and ultrastructural properties of the bovine pericardial affer different treatments were studied by the shrinkage temperature analysis and uniaxial load test. Results After the treatment, the thickness and stiffness of pericardium were increased, whereas the plasticity and flexibility were decreased, which became similar to the biomechanical properties of bioprosthesis. The modulus of elasticity of 2,3-butanediol post-treatment group is higher than that of glutaraldehyde-fixed group (8.75±1.71 versus 6.59±1.37, P<0.05), which was similar to that of nature valve tissue. The ultimate tensile stress of glutaraldehyde-fixed group was higher than that of 2,3-butanediol post-treatment group (P<0.005). Histological examination revealed some changes in structural organization of the collagen, which explained the alterations in the biomechanical properties. Conclusion The 2,3-butanediol post-treatment is a better method of treating bovine pericardial, which improved the biomechanical properties of bovine pericardial.

关 键 词：牛心包 戊二醛 2 3-丁二醇 生物力学特性 

分 类 号：R318.01[医药卫生—生物医学工程]