急性肾功能衰竭患者血浆PRA、AT-Ⅱ和Ald水平变化的临床分析  

Clinical Analysis of the Changes of Plasma PRA,AT-Ⅱand Ald Levels in Patients with Acute Renal Failure

作　　者：张秋岳 杨永青[1] 

机构地区：[1]苏州市第二人民医院,215002

出　　处：《放射免疫学杂志》2002年第6期321-322,共2页Journal of Radioimmanology

摘　　要：目的 :为了探讨血浆PRA、AT -Ⅱ和Ald在急性肾功能衰竭发病机理中的作用。方法 :我们应用放射免疫分析测定了 4 0名正常人和 72例急性肾功能衰竭病人血浆中的PRA、AT -Ⅱ和Ald的水平。结果 :72例急性肾功能衰竭病人血浆PRA、AT -Ⅱ和Ald明显高于 4 0名正常人 (p <0 0 5、p<0 0 1和p<0 0 0 1) ,普食卧位血浆PRA、AT -Ⅱ和Ald与 2 4h尿钠排出量为 89 1～ 36 5 2毫克当量的范围内无直线和指数的关系。结论Objective To investigate the role of changes of plasma PRA, AT-Ⅱ and Ald levels in the pathogenesis of acute renal failure. Methods Plasma PRA,AT-Ⅱ and Ald levels were defermined with RIA in 40 normal subjects and 72 cases of caute renal failure. Results Plasma PRA,AT-Ⅱ and Ald levels in the patients were markedly increased as compared with those in normal subjects ( p <0 05? p<0 01 ? p<0 001 respectively). There were no linearity and exponential relationship between plasma PRA,AT-Ⅱ?Ald levels and the 24h urinary sodium excretion amount (within the range of 89.1-365.2mEq). Conclusion Acute renal failure could activate the RAAS function.

关 键 词：临床分析 急性肾功能衰竭 血浆肾素活性 血管紧张素-Ⅱ 醛固酮 

分 类 号：R692.5[医药卫生—泌尿科学]