唾液酸与急性肺损伤发病关系的初步研究  

Relationship Between Sialic Acid and Acute Lunginjury

作　　者：刘宏 赵金垣[2] 王世俊[2] 汪整辉[2] 岳培瑶[2] 张亨山[2] 马东星[3] 

机构地区：[1]大同医专内科学教研室,教授037008 [2]北京大学第三医院 [3]武警总医院

出　　处：《大同医学专科学校学报》2002年第4期1-2,共2页Journal of Datong Medical College

摘　　要：目的:探讨唾液酸(SA)与急性肺损伤(ALI)发病的关系。方法:对油酸型肺损伤动物模型的外周血血小板、肺灌洗液(BALF)中的血小板激活因子(PAF)和SA进行测定,并与肺病理变化进行对照分析。结果:肺损伤动物外周血血小板减少,BALF中PAF活性和SA浓度增加,肺循环内有微血栓形成。结论:在急性肺损伤时,肺循环内有血小板的聚集和活化;血小板膜上的SA是平时保持肺循环正常状态的稳定因素之一。Objective:To study the relationship between sialic acid and the occurrence of acute lung injury. Methods:Peripheral platelet count and platelet-activating factor (PAF) activity and sialic acid(SA) content in brochoalveolar lavage fluid(BALF) were determined for rats wilh acute lung injury caused by oleic acid. Their pathological changes in the lungs were observed simultaneously. Results: Peripheral platelet count reduced and PAF activity and SA content in BALF increased in the animals with acute lung injury. Mi-crothrombosis could be seen in pulmonary circulation of the animals. Conclusions: In acute lung injury, aggregation and activation of platelet could be seen in pulmonary circulation, and SA on platelet membrane was one of the protective factors to maintain normal pulmonary circulation.

关 键 词：急性肺损伤 唾液酸 血小板活化 

分 类 号：R563[医药卫生—呼吸系统]