空腹C-P、INS及胰岛细胞自身免疫抗体诊断儿童1型糖尿病的价值  

Diagnostic value of fasting C-peptide and insulin levels and islets cell autoimmune antibodies to type 1 diabetes mellitus in children

作　　者：李桂梅[1] 薛江[1] 梁向荣[2] 马沛然[1] 陈力军[1] 高飞[1] 蒋莎义[1] 

机构地区：[1]山东省立医院,山东济南250021 [2]济南市儿童医院

出　　处：《山东医药》2002年第23期8-9,共2页Shandong Medical Journal

基　　金：山东省科学技术委员会科研奖励基金资助项目 (No.983 5 )

摘　　要：为探讨儿童初发 1型糖尿病 (T1DM)的诊断指标 ,对 33例 T1DM患儿 (观察组 )分别测定其空腹血糖(FPG)、糖化血红蛋白 (Hb A1 c)、C-肽 (C- P)、胰岛素 (INS)、胰岛细胞抗体 (ICA)及谷氨酸脱羧酶抗体 (GAD) ,并与 33例年龄、性别配对的健康儿童 (对照组 )作比较。结果显示 ,观察组除 FPG、Hb A1 c显著升高外 ,C- P、INS、C-P/ FPG、INS/ FPG均显著低于对照组 ,以 C- P/ FPG最明显。提示空腹 C-肽、INS、C- P/ FPG、INS/ FPG测定对诊断儿童初发 T1DM有重要价值 ;胰岛细胞自身免疫抗体测定对诊断To study the diadynamic criteria of type 1 diabetes mellitus(T1DM)in children .Fasting plasma glucose(FPG),HbA 1c,fasting C peptide(C P)and insulin(INS)levels and islets cell autoimmune antibodies(ICA)and glutamic acid decarboxylase antibodies (GAD)were measured in 33 patients with T1DM in children and in 33 healthy children matched with group T1DM in sex and age and compared these markers.Results showed that FPG,HbA 1c were significantly increased,fasting C P,INS levels and C P/FPG,INS/FPG were significantly decreased in group T1DM than in group control ,and C P/FPG was the most sensitive;The positive rate of ICA and GAD were significantly higher in group T1DM than in group control.These suggest fasting C P and INS levels and ICA and GAD have important diadynamic value in the diagnosis of T1DM in children.

关 键 词：C-肽 胰岛素 胰岛细胞抗体 谷氨酸脱羧酶抗体 1型糖尿病 

分 类 号：R725.871[医药卫生—儿科]