Synthesis and Antibacterial Activities of 4-Amino-3-(1-aryl-5-methyl-1,2,3-triazol-4-yl)-5-mercapto-1,2,4-triazoles/2-Amino-5-(1-aryl-5-methyl-1,2,3-triazol-4-yl)-1,3,4-thiadiazoles and Their Derivatives  

作　　者：张艳 孙小文 惠新平 张自义 王勤 张琪 

出　　处：《Chinese Journal of Chemistry》2002年第2期168-173,共6页中国化学（英文版）

基　　金：theNationalNaturalScienceFoundationofChina (QTProgram)

摘　　要：Treatment of 4-amino-3-(1-aryl-5-methyl-1,2,3-triazol-4-yl)-5-mercapto-1,2,4-triazoles/2-amino-5-(1-aryl-5-methyl-1,2,3-triazol-4-yl)-1,3,4-thiadiazoles with benzaldehyde,acetone and ω-bromoacetophenone was tested and compared. The title compounds Schiff bases, amides,imidazolo[2,1-b]-1,3,4-thiadiazoles and 7H-s-triazolo [3,4-b]-1,3,4-thiadiazines have been confirmedby elemental analyses, ~1H NMR, IR and MS spectra. All the compounds have also been screened fortheir antibacterial activities against B. subtilis, S. aureus and E. coli.Treatment of 4-amino-3-(1-aryl-5-methyl-1,2,3-triazol-4-yl)-5-mercapto-1,2,4-triazoles/2-amino-5-(1-aryl-5-methyl-1,2,3-triazol-4-yl)-1,3,4-thiadiazoles with benzaldehyde,acetone and ω-bromoacetophenone was tested and compared. The title compounds Schiff bases, amides,imidazolo[2,1-b]-1,3,4-thiadiazoles and 7H-s-triazolo [3,4-b]-1,3,4-thiadiazines have been confirmedby elemental analyses, ~1H NMR, IR and MS spectra. All the compounds have also been screened fortheir antibacterial activities against B. subtilis, S. aureus and E. coli.

关 键 词：schiff base amide imidazolo [2 1-4]-1 3 4-thiadiazole 7H-s-triazolo[3 4-b]-1 3 4-thiadiazine 

分 类 号：O626[理学—有机化学]