Synthesis of 4-Aryl-3,4-dihydropyrimidinones Using Microwave-assisted Solventless Biginelli Reaction  

作　　者：薛松 申晏才 李亚莉 沈小明 郭庆祥 

出　　处：《Chinese Journal of Chemistry》2002年第4期385-389,共5页中国化学（英文版）

基　　金：theResourceResearchBaseFoundationofUniversityofScienceandTechnologyofChinaandtheNationalNaturalScienceFoundationofChina (No.2 9972 0 38)

摘　　要：4-Aryl-3, 4-dihydropyrimidinones were synthesized using microwave-assisted,solvent-free protocol of the Biginelli reaction. The simple method provides the title compounds in78%―95% yields by the reaction of aromatic aldehydes with ethyl acetoac-etate and urea/thiourea inthe presence of a catalytic amount of cone. HCl. Lewis acids, such as ZnCl_2, SnCl_2, FeCl_3·6H_2O,and CuCl_2·2H_2O, were also found to be efficient catalysts for the synthesis ofdihydropyrimidinones.4-Aryl-3, 4-dihydropyrimidinones were synthesized using microwave-assisted,solvent-free protocol of the Biginelli reaction. The simple method provides the title compounds in78%―95% yields by the reaction of aromatic aldehydes with ethyl acetoac-etate and urea/thiourea inthe presence of a catalytic amount of cone. HCl. Lewis acids, such as ZnCl_2, SnCl_2, FeCl_3·6H_2O,and CuCl_2·2H_2O, were also found to be efficient catalysts for the synthesis ofdihydropyrimidinones.

关 键 词：DIHYDROPYRIMIDINONES microwave irradition biginelli reaction 

分 类 号：O625[理学—有机化学]