Optical Resolution of DL-Tartaric Acid Mediated by Diastereomeric Salts Crystallization: A Useful Method for Exploring and Optimizing Experimental Conditions  

作　　者：LolaKokila 蔡水洪 陈孔常 

机构地区：[1]Department of Chemical Engineering, Thermodynamics Research Center, East China University of Science & Tech-nology, Shanghai 200237, China

出　　处：《Chinese Journal of Chemical Engineering》2002年第2期244-248,共5页中国化学工程学报（英文版）

摘　　要：A response surface modeling approach for simultaneous optimization of optical purity and yield was applied to the resolution of tartaric acid to study the effects of both the amount of the solvent and the amount of the resolving agent a-methylbenzyl amine on the resolution results. The direction of changing the experimental conditions was determined from the initial response study, and expected high yield of the pure L(+)-tartaric acid-L(-)-a-methylbenzyl amine salt was obtained.A response surface modeling approach for simultaneous optimization of optical purity and yield wasapplied to the resolution of tartaric acid to study the effects of both the amount of the solvent and the amountof the resolving agent α-methylbenzyl amine on the resolution results. The direction of changing the experimen-tal conditions was determined from the initial response study, and expected high yield of the pure L(+)-tartaricacid-L(-)-α-methylbenzyl amine salt was obtained.

关 键 词：RESOLUTION optimization central composite rotatable design modeling 

分 类 号：O623[理学—有机化学]