Synthesis of Polyphosphonates Containing 5-Flouro-N^1-furanyl-N^3-glyceroalkyl-uracil and Formyl Groups  

作　　者：Li BAI Ru Yu CHEN Yuan Yuan ZHU 

机构地区：[1]Institute and National Key Laboratory of Elemento-Organic Chemistry,Nankai University,Tianjin 300071

出　　处：《Chinese Chemical Letters》2002年第1期29-32,共4页中国化学快报(英文版)

基　　金：This project was supported by the National Natural Science Foundation of China.

摘　　要：A series of novel polyphosphonates containing 5-flouro- N1-furanyl-N3- glyceroalkyl-uracil and formyl groups was synthesized by the condensation of 3-(w- (1-furanyl-5-flourouracil-3-yl) alkoxy)-1, 2-dihydroxy propane with phosphonyl dichloride. The products were characterized by IR, 1H NMR, 31P NMR, M, and elemental analysis. The results of bioassay show that compound 8a possesses potential anticancer activity.A series of novel polyphosphonates containing 5-flouro- N1-furanyl-N3- glyceroalkyl-uracil and formyl groups was synthesized by the condensation of 3-(w- (1-furanyl-5-flourouracil-3-yl) alkoxy)-1, 2-dihydroxy propane with phosphonyl dichloride. The products were characterized by IR, 1H NMR, 31P NMR, M, and elemental analysis. The results of bioassay show that compound 8a possesses potential anticancer activity.

关 键 词：POLYPHOSPHATES furanyl glyceryl 5-flourouracil formyl. 

分 类 号：O633[理学—高分子化学]