卡维地洛与美多心安治疗稳定型心绞痛的临床疗效比较  

Efficacy of carvedilol compared with metoprolol in stable angina

作　　者：张利华[1] 薛玉生[1] 赵季红[1] 刘军[1] 郑强荪[1] 肖俊平[2] 柳荫[1] 谢伯雅[1] 

机构地区：[1]第四军医大学唐都医院心内科,陕西西安710038 [2]第四军医大学唐都医院心电图室,陕西西安710038

出　　处：《心脏杂志》2002年第6期488-490,共3页Chinese Heart Journal

摘　　要：目的 :比较卡维地洛与美多心安治疗稳定型心绞痛 (SA)的临床疗效。方法 :将 SA患者随机分为卡维地洛治疗组 (n=80 )和美多心安治疗组 (n=76 ) ,观察用药 6周后治疗有效率以及心肌耗氧量 (RPP)和两组患者治疗期间的心血管危险事件发生率。结果 :1卡维地洛组临床治疗总有效率明显高于美多心安组 (92 % vs80 % ,P<0 .0 5 )。2卡维地洛组 RPP明显减少 ,用药前后分别为 (14 91± 2 2 5 ) k Pa· min- 1和 (12 32± 2 11) k Pa· min- 1 (P<0 .0 5 ) ;美多心安组用药前后分别为 (15 0 0± 2 70 ) k Pa· min- 1和 (14 99± 115 ) k Pa· min- 1 ,无显著差异 (P>0 .0 5 )。结论AIM:To evaluate the clinical effect of different β blockades in patients of stable angina(SA). METHODS: SA patients were randomly divided into two groups, one is the treatment goup( n =80) which was treated with carvedilol, the other is the control group( n =76) which was treated with metoprolol, and the clinical effective treatment, the rate pressure product (RPP) were observed after treated six weeks. RESULTS: ① The clinical effectiveness of the treatment group was significantly higher than the control group (92% vs 80% P <0.05).②RPP of the treatment group was significantly decreased than that before treated (1491±225) kPa·min -1 vs (1232±211) kPa·min -1 ( P <0.05), But it was no significant difference in the control group(1500±270) kPa·min -1 vs (1499±115) kPa·min -1 ( P >0.05). ③The cardiovascular episodes of the treatment group were significantly decreased than that of the control group( P <0.05). CONCLUSION: The clinical effect of carvedilol was much better than that of metoprilol.

关 键 词：Β-受体阻滞剂 卡维地洛 美多心安 不稳定型心绞痛 治疗 

分 类 号：R541.405[医药卫生—心血管疾病]