常青胶囊对大鼠致畸作用的影响  

Study on Teratogenic Effects of Changqing Capsule in Rates

作　　者：李鸣[1] 林健[2] 

机构地区：[1]福建省药品检验所,福州350001 [2]福建省卫生防疫站,福州350001

出　　处：《海峡药学》2002年第6期24-25,共2页Strait Pharmaceutical Journal

摘　　要：目的　观察常青胶囊对大鼠致畸敏感期的毒性。方法 　采用灌胃给药 ,观察对孕鼠的体重、胎仔数、胎仔体重、活胎数、死胎数、吸收胎数以及对胎鼠骨骼发育和内脏畸形率的影响。结果 　常青胶囊对大鼠胚胎毒性和致畸潜力与空白对照组比较无显著性差异。结论OBJECTIVE To detect toxicity of Changqing Capsule in rats during teratogenic sensitive period.METHODS Changqing Capsule was force fed to gestation rats.The weight both of the gestation rats and the fetuses was examined.The number of implantations,livings,deaths and absorbed fetuses was measured.Then the effects on skeletal development and the rate of internal organs malformation in the fetuses were analysed,too.RESULTS There were no significant differences as compared with negative control groups both on Embryo toxicity and teratogenicity.CONCLUSION Changqing Capsule had no teratogenic effect on rats.

关 键 词：影响 常青胶囊 大鼠致畸 

分 类 号：R965.3[医药卫生—药理学]