免加热工艺大黄提取物与生大黄、熟大黄提取物的药效比较  

Drug Effect Comparison of Rhubarb Extract by the Technology Free of Heating and the Extracts form Crude Rhubarb and from Prepaed Rhubarb

作　　者：胡迎庆[1] 王中军[1] 宋月英[1] 邓昌沪 

机构地区：[1]中国人民武装警察部队医学院,天津300162 [2]厦门今润医药科学发展有限公司

出　　处：《中药材》2002年第12期893-895,共3页Journal of Chinese Medicinal Materials

基　　金：国家科技部中小企业科技基金资助项目

摘　　要：目的:研究免加热工艺大黄提取物与传统工艺生大黄、熟大黄提取物对小鼠肠运动的影响和镇痛作用进行比较。方法:用墨汁作为指示剂,测定不同工艺大黄提取物给药后墨汁在肠道的推进距离,比较药物对小鼠小肠蠕动的影响;采用热板法和醋酸扭体法对不同工艺大黄提取物镇痛作用进行比较。结果:小剂量(0.75 mg·g-1)免加热工艺大黄提取物泻下作用较缓,与熟大黄高剂最作用相当;小剂量(0.50 mg·g-1)镇痛作用效果与熟大黄中、高剂量组和生大黄的高剂量组相当。结论:免加热工艺大黄提取物小剂量具显著作用;免加热提取工艺的应用可减少大黄用药量,节约药物资源。Objective: To study the effects of rhubarb extract by the technology free of heating ( RETFH) and the extracts from crude rhubarb and from prepared rhubarb on intestine movement and analgesia in mice, and to compare the effects each other. Methods: Intestine movement was studied by determining the distance in intestine after administrating the extracts from different technology with ink as indicator. Analgesia effect was studied by hot plate test and torsion test induced by acetic acid for the extracts from different techology. Results: Diarrhea effect of low dose (0.75mg/g) RETFH was moderate, and equal to that of high dose (3.00 mg/g) extract from prepared rhubarb. Remarkable analgesia effect of low dose(0.50mg/g) RETFH was equal to that of middle and high dose (2.00 mg/g,4.00 mg/g) extracts from prepared rhubarb and high dose (4.00 mg/g) extract from crude rhubarb. Conclusion; 0.50 mg/g RETFH possessed obvious diarrhea and analgesia effects . To utilize the technology free of heating may decrease dosage of rhubarb and save medicinal resource.

关 键 词：免加热工艺 大黄 提取物 生大黄 熟大黄 药效 比较 

分 类 号：R285.5[医药卫生—中药学] R282.[医药卫生—中医学]