冠心病患者血清胆红素和尿酸的变化及相关性  

The study on the changes of serum bilirubin and uric acid in patients with coronary heart disease and their relationship

作　　者：施根林[1] 何海明[1] 周宁[1] 王国宝[1] 

机构地区：[1]武警江苏总队医院检验科,扬州225003

出　　处：《武警医学院学报》2003年第1期36-38,共3页Acta Academiae Medicinae CPAPF

摘　　要：目的 :观察冠心病患者血清胆红素、尿酸含量变化及其临床意义。方法 :采用比色法及酶法测定 3 9例冠心病患者及 3 0例健康者 (对照组 )血清胆红素、尿酸含量。结果 :冠心病患者血清直接胆红素、尿酸含量较对照组明显升高 (P <0 0 1) ,血清间接胆红素含量明显低于对照组 (P <0 0 1) ,血清总胆红素与对照组比较差异无显著性 (P >0 0 5 ) ;心肌梗死组血清总胆红素、直接胆红素、间接胆红素及尿酸含量与心肌缺血组比较无显著性差异 (P >0 0 5 ) ;心肌缺血组心功能Ⅲ～Ⅳ级患者血清尿酸含量较心功能Ⅰ～Ⅱ级患者升高显著 (P<0 0 5 ) ,血清总胆红素、直接胆红素、间接胆红素含量变化与心功能分级关系不明显 ;经相关分析 ,冠心病患者血清总胆红素、直接胆红素、间接胆红素与尿酸含量间无相关性 (P >0 0 5 )。结论 :胆红素。Objective:To study the changes of serum bilirubin and uric acid in patients with coronary heart disease(CHD)and their clinical significance.Methods:The serum levels of bilirubin and uric acid were determined by colorimetry and enzymatic assay in 39 patients with CHD and in 30 healthy controls.Results:The serum levels of direct bilirubin and uric acid in CHD patients were markedly higher than those in control group( P <0 01),the serum levels of indirect bilirubin was markedly lower than those in control group( P <0 01),the serum levels of total bilirubin was no difference than those in control group( P >0 05).the serum levels of total bilirubin,direct bilirubin,indirect bilirubin and uric acid in myocardial infarction were no difference than those in myocardial ischemia( P >0 05).In myocardial ischemia,the serum levels of uric acid in heart function stage Ⅲ～Ⅳ was more higher than those in heart function stage Ⅰ～Ⅱ( P <0 05),the serum levels of total bilirubin,direct bilirubin and indirect bilirubin were unrelated to heart function stage.the serum levels of total bilirubin,direct unrelated to heart function stage.the serum levels of total bilirubin,direct bilirubin and indirect bilirubin in CHD patients were unrelated with uric acid( P >0 05).Conclusion:Bilirubin and uric acid may play an important roles in the pathogenesis of CHD.

关 键 词：冠心病 血清 胆红素 尿酸 变化 相关性 

分 类 号：R541.4[医药卫生—心血管疾病]