氯沙坦治疗糖尿病肾病52例  

Clinical effect of losartan on 52 patients with diabetic nephropathy

作　　者：王艳军[1] 张金苹 韩萍[1] 卢丽萍[2] 

机构地区：[1]中国医科大学第二临床学院内分泌科,沈阳110004 [2]中国医科大学第二临床学院检验科,沈阳110004

出　　处：《中国新药杂志》2002年第12期956-958,共3页Chinese Journal of New Drugs

摘　　要：目的 :探讨血管紧张素Ⅱ (AngⅡ )受体阻断剂氯沙坦对糖尿病肾病 (DN)的治疗和保护作用与机制。方法 :5 2例患者随机分为氯沙坦 5 0mg组 (n =2 7)和 10 0mg组 (n =2 5 ) ,分别服氯沙坦 5 0和 10 0mg·d-1,po,qd ,疗程 8周。观察服药前后血压、血钾、血尿酸、2 4h尿白蛋白排泄率 (UAE)及血清中AngⅡ、一氧化氮 (NO)、内皮素(ET)、转化生长因子 β1(TGF β1)的变化。结果 :服用氯沙坦后 ,患者的血压、血尿酸和UAE ,ET ,TGF β1均下降 ,血钾无明显升高 ,AngⅡ和NO升高。 10 0mg组比 5 0mg组作用明显。 结论 :氯沙坦不仅通过对AngⅡ的作用 ,而且还可通过对NO ,ET ,TGF β1的影响来达到对DN的治疗和保护作用。Objective:To explore the therapeutic and protective effect and mechanism of antagonists of angiotensin Ⅱ receptor losartan on diabetic nephropathy(DN).Methods:52 patients were divided into the group Ⅰ( n =27) and groupⅡ( n =25) to receive losartan 50mg and 100mg daily, po ,qd for 8 weeks respectively.The alteration of blood pressure, serum kalium,serum uric acid, urine albumin excretion,serum AngⅡ,nitric oxide (NO), endothelin(ET), and transforming growth factor β 1 (TGF β 1) before and after treatment were observed.Rusults:After usage of losartan, the blood pressure, serum uric acid, 24 hours'UAE,ET and TGF β 1 decreased,and the Ang Ⅱ,NO increased.There was no obvious elevation of serum kalium.The effect were more obvious in the 100mg group than that in the 50mg groups.Conclusion:Losartan possesses the therapeutic and protective effect on DN,its mechanism may be associated with AngⅡ,NO,ET and EGF β 1. [

关 键 词：氯沙坦 治疗 糖尿病肾病 血管紧张素Ⅱ 一氧化氮 内皮素 转化生长因子Β 

分 类 号：R587.2[医药卫生—内分泌] R972.[医药卫生—内科学]