利用三溴化铟催化的Biginelli反应原位合成3,4-二氢嘧啶-2-酮  

A Novel One-pot Synthesis of 3,4-Dihydropyrimidine-2(1H)-ones Catalyzed by Indium Tribromide

作　　者：傅南雁[1] 袁耀锋[1] 庞美丽[1] 王积涛[1] 

机构地区：[1]南开大学化学系,天津300071

出　　处：《高等学校化学学报》2003年第1期79-81,共3页Chemical Journal of Chinese Universities

基　　金：国家自然科学基金 (批准号 :2 9872 0 18;2 9972 0 2 6 );南开大学元素有机国家重点实验室和教育部博士学科点基金 (批准号 :19990 0 5 5 2 0 )资助

摘　　要：A novel catalyst indium(Ⅲ) tribromide is shown to efficiently promote 5-carbonyl-4-aryl-3,4-dihydropyrimidin-2(1H)-ones from a three-component coupling of β-diketones, aldehydes and urea in ethanol. This modified one-pot Biginelli′s cyclocondensation not only features simple operation, but also takes place in nonpolluted environment. The structure of the Biginelli reaction product from β-diketones, salicylaldehyde and urea has been proposed to possess an oxygen-bridge.A novel catalyst indium(Ⅲ) tribromide is shown to efficiently promote 5-carbonyl-4-aryl-3,4-dihydropyrimidin-2(1H)-ones from a three-component coupling of β-diketones, aldehydes and urea in ethanol. This modified one-pot Biginelli′s cyclocondensation not only features simple operation, but also takes place in nonpolluted environment. The structure of the Biginelli reaction product from β-diketones, salicylaldehyde and urea has been proposed to possess an oxygen-bridge.

关 键 词：合成 3 4-二氢嘧啶-2-酮 BIGINELLI反应 三溴化铟 氧桥 催化剂 

分 类 号：O626.41[理学—有机化学] O643.32[理学—化学]