急性病毒性心肌炎血清肌钙蛋白Ⅰ的表达及临床意义  

Clinical significance of serum troponin Ⅰ in patients with viral myocarditis

作　　者：余新超[1] 郑芙林[1] 汪思应[2] 刘燕驹[1] 

机构地区：[1]安徽理工大学医学院,淮南232001 [2]安徽医科大学基础医学院

出　　处：《中国基层医药》2002年第12期1067-1068,共2页Chinese Journal of Primary Medicine and Pharmacy

摘　　要：目的　观察病毒性心肌炎 (VMC)病人血清肌钙蛋白Ⅰ (cTnⅠ )水平变化 ,探讨cTnⅠ对VMC的诊断价值。方法　选择符合VMC诊断标准的首诊VMC病人 5 4例 ,根据心电图 (ECG)表现分为三组 :A组 (正常组 )、B组 (单项异常组 )和C组 (重叠异常组 ) ,用ELISA法测定入院 2周内血清cTnⅠ的浓度。 32例健康志愿者为对照组。结果　 5 4例急性期VMC病人中 ,有 38例血清cTnⅠ阳性 ;血清cTnⅠ水平VMC组显著高于对照组 (11 5± 4 6 3vs 1 87± 0 74 ,P <0 0 0 1) ;C组、B组均显著高于A组 (18 86± 7 35、12 12±6 15vs 7 76± 2 71,P <0 0 2和P <0 0 1) ,C组显著高于B组 (18 86± 7 35vs 12 12± 6 15 ,P <0 0 1)。结论　测定cTnⅠ水平可作为VMC早期诊断指标 ,对病情判断有重要的临床价值。Objective To observe the alteration of serum troponin Ⅰ(cTnⅠ) in patients with viral myocarditis(VMC),and to assess the diagnostic values of cTnⅠ in acute viral myocarditis.Methods cTnⅠ was detected in 54 patients with VMC and compared with 32 healthy volunteers(control subjects).The VMC patients were divided into three groups:normal ECG group(group A),one abnormal ECG group(group B) and two or more abnormal ECG group(group C).Results The positive rate and the level of cTnⅠ were higher in VMC groups than those in control group(P<0.01,respectively).And the levels of cTnⅠ in group B and C were higher than those in group A(12.12±6.15,18.86±7.35 vs 7.76±2.71,P<0.02 and P<0 01,respectively)and the level of cTnⅠ in group C was significantly higher than that in group B(18.86±7.35 vs 12.12±6.15,P<0.01).Conclusion Troponin Ⅰ is a sensitive and specific marker in the patients with VMC.It can be helpful in the early diagnosis of myocardial injury.Quantitation detection of cTnⅠ can evaluate the progress of VMC.

关 键 词：急性病毒性心肌炎 血清 肌钙蛋白Ⅰ 临床意义 诊断 

分 类 号：R542.21[医药卫生—心血管疾病]