当归抗大鼠免疫性肝纤维化的实验研究  

An Experimental Study on the Antagonistic Effect of Danggui on the hepatic Fibrosis of Rats

作　　者：陈斌[1] 孙克伟[1] 谢凤瑛[1] 陈翔[1] 葛金文 

机构地区：[1]湖南中医学院第一附属医院,湖南长沙410007

出　　处：《湖南中医学院学报》2002年第4期1-3,共3页Journal of Hunan College of Traditional Chinese Medicine

基　　金：国家中医管理局重大项目(95A1116);湖南省卫生厅重点项目(98111)

摘　　要：目的研究当归抗肝纤维化的作用及机理。方法采用牛血清白蛋白 (BSA)致大鼠免疫损伤性肝纤维化模型 ,观察当归大、小剂量对其肝功能、超氧化物歧化酶 (SOD)、丙二醛 (MDA)及肝细胞膜功能的影响。结果当归尤其是小剂量当归具有明显提高肝细胞SOD、降低MDA的作用 (P <0 .0 5 ) ,并能提高肝细胞膜ATP酶 (ATPase)活性 (P <0 .0 5 )。结论提示当归具有明显的抗肝纤维化作用 ,且小剂量优于大剂量。?Objective To observe the antagonistic effect of Danggui on hepatic fibrosis among rats. Methods Immuno injuring induced hepatic fibrosis among rats was prepared by bovine serum albumin and experimental treatment was carried out for them with this herb. Then, the therapeutic effects on hepatic fibrosis of rats were determined. Results Compared with the model group,the activity of SOD in plasma of hepatocytes and ATPase in the membrane of hepatocytes were significantly increased in the group of small dosage of Danggui (P<0.05) and MDA in plasma of hepatocytes was remarkably decreased in this group(P< 0.05 ).Conclusion Danggui has positive effect to inhibit experimental hepatic fibrosis among rats, especially when used in small dosage . 〔

关 键 词：当归 肝纤维化 实验 动物 大鼠 

分 类 号：R285.5[医药卫生—中药学] R259.[医药卫生—中医学]