溶脲脲原体对四环素类和大环内酯类抗生素的耐药性及其与血清型的关系  

Study on resistance of Ureaplasma urealyticum to tetracyclines and macrolides and its relationship with serotype

作　　者：朱慧兰[1] 陈荣章[2] 谷进[2] 陆春[2] 赖维[2] 徐广坤[2] 

机构地区：[1]广州市皮肤病防治所,510095 [2]中山大学第三附属医院

出　　处：《中国抗感染化疗杂志》2002年第4期197-199,共3页Chinese Journal of Infection and Chemotherapy

摘　　要：目的 :了解耐四环素类和大环内酯类溶脲脲原体 (Uu)的发生率和特性 ,探讨耐四环素Uu与血清型的关系。方法 :用微量肉汤稀释法对从性传播疾病 (STD)病人分离出来的 5 0株Uu菌株进行体外药敏试验和代谢抑制试验作血清学分型。结果 :Uu对四环素、多西环素、红霉素耐药率分别为 36 % (18/ 5 0 )、10 % (5 / 5 0 )和 5 0 % (2 5 / 5 0 ) ;且四环素、多西环素和红霉素存在交叉耐药。用代谢抑制试验对 10株四环素耐药和 10株四环素敏感的Uu菌株进行血清学分型 ,发现两者之间血清学分布无差异 (P >0 .0 5 ) ,但以Uu4型菌株常见。结论 :Uu对四环素、多西环素和红霉素存在交叉耐药 ,Uu菌株耐药性与血清学分布无明显差异 。Objective: To investigate the incidence and characteristics of tetracyclines and macrolides resistant in Ureaplasma urealyticum (Uu) isolates, and the relationship between antimicrobial resistance and serotypes. Methods: The MICs of 50 strains of Uu isolated from STD patients were measured by micro dilution method, and metabolic inhibition test was used for typing. Results: The resistance rates to tetracycline, doxycycline and erythromycin were 36%(18 /50), 10%(5 /50) and 50%(25 /50) respectively, and there was cross resistance among tetracycline, doxycycline and erythromycin. No statistical difference in serotyping distribution between tetracycline resistant and susceptible strains ( P >0.05), and strains of serotype 4 was more frequenty isolated. Conclusions: Cross resistance to tetracycline, doxycycline and erythromycin exists in Uu strains. The serotype of Uu strains has no correlation with tetracycline resistance, and serotype 4 strains were more frequently seen.

关 键 词：溶脲脲原体 四环素 大环内酯类抗生素 耐药性 血清型 

分 类 号：R446.5[医药卫生—诊断学]