粉防己碱对肾性高血压大鼠小血管重构的影响  

Effect of Tetrandrine on Resistance Vessels Remodeling in Renovascular Hypertensive Rats

作　　者：彭韬[1] 李庆平[2] 

机构地区：[1]南京医科大学病理学系,江苏南京210029 [2]学南京医科大学药理学与神经生物学系,江苏南京210029

出　　处：《南京医科大学学报（自然科学版）》2003年第1期8-10,50,共4页Journal of Nanjing Medical University(Natural Sciences)

基　　金：江苏省自然科学基金资助项目(BK97049)

摘　　要：目的:探讨肾血管性高血压大鼠小血管重构特点及粉防己碱的预防作用。方法:用两肾一夹法制备肾血管性高血压大鼠病理模型,术后第5周给予粉防己碱(Tet,50 mg·kg-1·d-1)或依那普利(Ena,6mg·kg-1·d-1)连续8周,观察两药对高血压大鼠小动脉血管结构的影响。结果:肾血管性高血压(RH)大鼠尾动脉和股动脉湿重增加;尾动脉、冠状动脉、肾小动脉管壁厚度和壁/腔比值均明显增大;肾小动脉管壁平滑肌细胞数明显增加。粉防己碱和依那普利用药后上述变化明显减轻。结论:肾血管性高血压大鼠小动脉主要呈肥厚性重构。粉防己碱和依那普利可有效防止RH大鼠小血管重构。Objective To study the character of vascular morphological changes and the preventive effect of tetrandrine in renovas-cular hypertensive(RH) rats. Mehtods: Renovascular hypertension was induced by two kidney one clip(2K1G) operation. Morphometumeasurements were performed m caudal artery, renal arterioles, and coronary arterioles. Results: The wet weight of aorta, caudalartery and femvral artery of RH rats(12 weeks after 2K1G operation) were greater than those of sham-operated rats. The parietalthickness, lumen caliber, and the ratio of parietal thickness to lumen caliber of abdomen aorta, caudal artery, coronary arterioles, and re-nal arterioles were significantly increased. There were no significant changes in the number of vascular smooth muscle cells(VSMC) inmost vessels, except the renal arterioles, where the number of VSMC was significantly increased. After the administration of tetrandine(50 mg ·?kg-1·?d-1 ,po) or enalapril (Ena, 6 mg ·kg-1·?d-1 ,po) for 8 weeks, the parietal thickness, the ratio uf parietal thickness to lumen caliber, and the wet weight were decreased. Conclusion : The most important change of arterioles is hypertrophic remodel-ing in the RH rats, with a proliferation of VSMC in renal arterioles, which may be prevented by tetrandrine and enalapril.

关 键 词：粉防己碱 肾血管性高血压 血管重构 两肾一夹法 血管组织学 血管形态学 

分 类 号：R544.14[医药卫生—心血管疾病] R965[医药卫生—内科学]