慢性扁桃体炎患者手术治疗前后细胞免疫功能的变化  

Effect of tonsillectomy treatment on cellular immune function in patients with chronic tonsillitis

作　　者：姚榕威 欧阳绍基 谢凤梅[1] 胡全福[1] 

机构地区：[1]南方医科大学第五附属医院耳鼻喉科,广东广州510900

出　　处：《海南医学》2016年第15期2533-2534,共2页Hainan Medical Journal

摘　　要：目的探讨手术对慢性扁桃体炎患者细胞免疫功能的影响。方法选择2014年1月至2015年10月期间在我院耳鼻喉科行扁桃体剥离术治疗的30例慢性扁桃体炎患者纳入观察组,20例健康体检者纳入对照组,检测对照组外周血T淋巴细胞亚群水平,以及观察组患者手术前后外周血T淋巴细胞亚群水平,并进行比较分析。结果观察组患者手术前的血清CD3^+、CD4^+及CD4^+/CD8^+比值分别为(57.34±5.82)%、(28.75±4.91)%及(1.12±0.22),均明显低于对照组的(67.29±8.25)%、(35.58±5.76)%及(1.27±0.29),差异均有统计学意义(P<0.05);治疗后,观察组患者的血清CD3^+、CD4^+及CD4^+/CD8^+分别为(65.26±6.91)%、(33.16±5.54)%及(1.26±0.26),较治疗前明显升高,差异均有统计学意义(P<0.05)。结论慢性扁桃体炎可造成患者免疫功能下降,而手术切除扁桃体后可使患者的免疫功能短期内得到恢复。Objective To explore the effect of surgery on immune cell function of patients with chronic tonsillitis. Methods A total of 30 cases with chronic tonsillitis treated by tonsillectomy in Department of ENT of our hospital from January 2014 to October 2015 were selected as the observation group, and 20 cases of healthy people were included into the control group. The peripheral blood T lymphocyte subsets in control group were detected, and that before and after operation in the observation group were detected. Results The serum CD3+,CD4+,CD4+/CD8+[(57.34 ±5.82)%,(28.75 ± 4.91)%,(1.12 ± 0.22), respectively] in the observation group were significantly lower than those in the control group [(67.29±8.25)%,(35.58±5.76)%,(1.27±0.29), respectively], P<0.05; After the treatment, the serum CD3+,CD4+,CD4+/ CD8+[(65.26±6.91)%,(33.16±5.54)%,(1.26±0.26), respectively] in the observation group were significantly higher than before treatment, P<0.05. Conclusion Chronic tonsillitis can decrease the immune function of patients, while tonsillectomy can recovery the immune function of the patients in the short term.

关 键 词：慢性扁桃体炎 扁桃体剥离术 细胞免疫 影响 

分 类 号：R766.9[医药卫生—耳鼻咽喉科]