50岁以下冠心病患者冠脉病变特点及其危险因素的研究  

A study on the lesion of coronary artery and the correlative risk factors in patients with coronary artery disease under 50 years old in Beijing area

作　　者：卢清玉[1] 张伶[1] 徐冬梅[1] 黄慧贤[1] 杨静文[1] 李江虹[1] 吴建国[1] 

机构地区：[1]北京市海淀区医院心内科,100080

出　　处：《实用心脑肺血管病杂志》2002年第6期328-330,共3页Practical Journal of Cardiac Cerebral Pneumal and Vascular Disease

摘　　要：目的　分析探讨 5 0岁以下冠心病患者的冠状动脉 (冠脉 )病变特点及危险因素。　方法　将生活于北京地区的 12 8例 5 0岁以下因冠心病或怀疑冠心病而行冠脉造影的患者 ,根据造影结果分为冠心病组 (70例 )和非冠心病组 (5 8例 ) ,除分析其冠脉病变特点外 ,并将其危险因素对照分析。　结果　前降支受累率最高 ,为 78 6 %。男性多支病变多于女性 (P <0 0 5 )。冠心病家族史在两组间有显著差异 (P <0 0 5 )。载脂蛋白A1 (apoA1 )、总胆固醇与高密度脂蛋白比值 (TC/HDL)及载脂蛋白A1 与载脂蛋白B比值 (apoA1 apoB)在两组间均有显著差异 (P <0 0 5 )。　结论　冠脉病变男性重于女性 ,冠心病家族史是重要危险因素。apoA1 和TC HDL及apoA1 apoB对预测冠心病有一定意义。Objective To study lesions of coronary artery and the correlative risk factors in patients with coronary artery disease(CAD) under 50 years old in Beijing area Methods 128 cases(<50 years old) after coronary angiography(CAG) were divided into 2 groups There were 70 cases with lesions of coronary artery as group Ⅰ,the others(58 cases) without lesions were group Ⅱ All the charactistic of the pathologe changes in coronary artery and the correlative risk factors were investigated Results In group Ⅰ,the lesion was common in left descending anterior branch(78 6%),and the multibranch lesions were more in male patients than female(56% vs 20%,P<0 05) Between group Ⅰ and group Ⅱ the family history of CAD and apoA 1 and TC/HDL and apoA 1/apoB were significantly different(P<0 05) Conclusion Lesions of coronary artery are more severe in male than in female Family history of CAD is a very important risk factor in young patients apoA 1 and TC/HDL and apoA 1/apoB had some value in a certain sense for the prediction of coronary artery disease

关 键 词：冠心病 青年人 危险因素 载脂蛋白A1 总胆固醇 高密度脂蛋白 比值 

分 类 号：R541.4[医药卫生—心血管疾病]