环磷酰胺分别联合甲泼尼龙、泼尼松治疗活动性狼疮肾炎的对比研究——附72例分析  

The comparative study between cyclophosphamide plus methylprednisolone and plus prednisone on the treatment of patients with active lupus nephritis

作　　者：余国洪[1] 李志坚[1] 

机构地区：[1]中山大学附属第一医院肾内科,510080

出　　处：《新医学》2002年第12期718-719,共2页Journal of New Medicine

摘　　要：目的:比较环磷酰胺联合甲泼尼龙双冲击疗法与环磷酰胺冲击疗法联合口服泼尼松疗法治疗活动性狼疮肾炎的临床疗效。方法:回顾性分析72例活动性狼疮肾炎患者的临床资料,其中37例采用环磷酰胺联合甲泼尼龙进行双冲击疗法(A组)、35例采用环磷酰胺冲击疗法联合口服泼尼松疗法(B组),比较两组的疗效及不良反应。结果:A组起效时间犤(8±1)日犦较B组犤(12±1)日犦快,(P<0.05);治疗3个月、6个月、12个月时累计缓解率A组分别为57%、71%、86%,B组分别为29%、43%、69%(均为P<0.01);不良反应发生率A组比B组高(P<0.05)。结论:环磷酰胺联合甲泼尼龙双冲击疗法治疗活动性狼疮肾炎能提高病情缓解率,但不良反应较大。Objective:To compare the efficacy of two regimens,cyclophosphamide (CTX) plus methylprednisolone or prednisone,on the treatment of active lupus nephritis. Methods:Data were collected from seventy two patients with active lupus nephritis.The comparative study was performed in two groups:group A (37 cases) pulse therapy with CTX combined with methylprednisolone;group B (35 cases) pulse therapy with CTX combined with oral prednisone.The efficacy of the two regimens was evaluated at three months,six months and twelve months after initiation of the therapies.Results:The onset of the treatment effect in group A was much earlier than that in group B (P<0.05). The rate of remission of group A was also much higher than that of group B (P<0.01). However,the side effects were more common in group A than in group B (P<0.05). Conclusion:The combination pulse therapy with CTX and methylprednisolone is more effective on the treatment of active lupus nethritis,although more common untoward reactions were seen.

关 键 词：系统性红斑狼疮 狼疮性肾炎 环磷酰胺 甲泼尼龙 泼尼松 疗效 冲击疗法 SLE 病理类型 

分 类 号：R593.242[医药卫生—内科学] R96[医药卫生—临床医学]