谷氨酸对伏隔核痛反应神经元放电的影响  

Effects of glutanuc acid on discharge of pain-related neurons in nucleus accumbens

作　　者：张秀娟[1] 徐满英[1] 吕宁[1] 闫彬彬[1] 

机构地区：[1]哈尔滨医科大学生理学教研室,黑龙江哈尔滨150086

出　　处：《哈尔滨医科大学学报》2002年第6期425-427,共3页Journal of Harbin Medical University

基　　金：国家自然科学基金资助项目(30240058);黑龙江省科技攻关项目(GC01Cl41-01)

摘　　要：目的 研究脑室内注入谷氨酸(Glu)对伏隔核(NAcc)痛反应神经元放电的影响。方法 细胞外记录神经元放电。结果①伤害性刺激可使NAcc内痛兴奋神经元(PEN)电活动增加,使痛抑制神经元(PIN)电活动减少。②脑室内注入Glu可使NAcc内PEN诱发放电频率增加。潜伏期缩短;使PIN诱发放电频率减少,抑制时程延长。结论脑室注入Glu可使NAcc内痛反应神经元对伤害性刺激的反应加强,表现出Glu易化疼痛效应。Objective To study the influence of intracerebroventricular injection of glutamic acid(Glu) on discharge of pain-related neurons in nucleus accumbens(NAcc) .Methods The discharge frequency of neurons was recorded by extracellular recording. Results (1)The noxious stimulation increased the electric activities of pain-excitation neurons(PEN) and decreased the electric activities of pain-inhibition neurons(PIN) . (2)The intracerebroventricular injection of Glu caused an increase of the evoked discharge frequency of PEN and the shortening of latency as well as a reduction of the evoked discharge frequency of PIN and a prolongation of inhibitory duration. Conclusion The response of pain-related neurons in NAcc on the noxious stimulation is potentiated by the intracerebroventricular injection of Glu, i.e. exhibiting the excited pain effect of Glu.

关 键 词：谷氨酸 伏隔核 痛兴奋神经元 痛抑制神经元 电活动 

分 类 号：R338.8[医药卫生—人体生理学]