血清Ⅲ型前胶原肽、Ⅳ型胶原和层粘连蛋白测定在诊断慢性肝疾病中的应用  

Application of type III procollagen peptide,type IV collagen and laminin in diagnosis of chronic liver disease

作　　者：姚敏捷[1] 黄汉朝[1] 梁兆祥[1] 李艳[1] 

机构地区：[1]第四军医大学吉林军医学院,吉林132013

出　　处：《哈尔滨医科大学学报》2002年第6期479-480,共2页Journal of Harbin Medical University

摘　　要：目的探讨血清Ⅲ型前胶原肽(PⅢP)、Ⅳ型胶原(COLⅣ)和层粘连蛋白(LN)与慢性病毒性肝病及肝纤维化诊断的关系。方法 测定24例慢性病毒性肝病和9例晚期肝硬变患者血清PⅢP、COLⅣ、LN及肝功能实验,同时做了肝组织活检。结果 PⅢP、COLⅣ、IN 随着慢性肝病加重含量逐渐增高,与正常对照差异显著(P<0.01);与肝组织学改变有明显相关性。结论PⅢP、COLⅣ、LN对慢性病毒性肝病纤维化的发生、发展有重要的临床参考价值。Objective To explore the correlation between type HI procollagen peptide (PIIIP) ,type IV collagen (COLIV) ,laminin(LN) and diagnosis of cirrhosis, chronic viral hepatitis.Methods The serum content of PIII P, COLIV , LN in 24 patients with chronic hepatitis and 9 patients with liver cirrhosis were determined by EIA,the serum levels of ALT, AST, ALP and Bil were measured in all of the patients and these values were compared with liver histological findings. Results Serum levels of PIIIP,COL IV and LN increased with the progress of liver disease in patients with chronic viral liver disease and were significantly higher than those in the controls (P < 0.01). It was correlated with the histological changes of liver. Conclusion Serum PIII P, COLIV , LN are fairly well correlation with staging of fibrosis and these test could be useful for diagnosing cirrhosis in patients with chronic viral liver disease.

关 键 词：Ⅲ型前胶原肽 Ⅳ型胶原 层粘连蛋白 肝硬变 慢性病毒性肝炎 肝功能 诊断 

分 类 号：R512.6[医药卫生—内科学] R575.[医药卫生—临床医学]