硝酸甘油贴膜抗早产作用实验研究  

Effect of nitroglycerin patch arresting preterm labor

作　　者：贺茜[1] 沙金燕[1] 邢玉凯[2] 崔英[1] 惠宁[1] 张俊洁[1] 张黎明[3] 

机构地区：[1]第二军医大学长海医院妇产科,上海200433 [2]中国药科大学 [3]第二军医大学海军医学系防化医学教研室,上海200433

出　　处：《中国药理学通报》2002年第6期629-631,共3页Chinese Pharmacological Bulletin

基　　金：国家自然科学基金资助课题 No 39670 75 7

摘　　要：目的　以合适的动物模型评价NO供体药物硝酸甘油贴膜的抗早产作用。方法　本试验采用了 2种动物模型 :延缓大鼠已启动分娩过程模型和推迟晚期妊娠家兔分娩启动模型。结果　前一模型硝酸甘油贴膜低、高剂量组第 1只和第 2只仔鼠娩出的时间间隔分别为 (111± 5 5 )min和 (13 0± 5 0 )min ,与阴性对照组 (2 2± 1)min相比差异有统计学意义 (P <0 0 1) ,延迟第 2只仔鼠的分娩。后一模型中 ,硝酸甘油贴膜低、高剂量组比阴性对照组分别延长妊娠时间 1d和 2d(P <0 0 1) ,推迟妊娠晚期家兔的分娩启动。AIM To observe the effect of nitroglycerin patch arresting preterm labour in animal models METHODS Two models are utilized to evaluate the effect of nitroglycerin patch, which include the measure of spontaneous delivery time between the first and second pups in term pregnancy rats and the delay in the onset of labor in rabbits RESULTS In the first model, spontaneous delivery time between the first and second pups in term pregnancy rats in low and high dose groups were (111±55) min and (130±50) min respectively,which was significantly longer than that in negative control (22±1) min In the second model, the onset of labor in rabbits was delayed 1 and 2 day respectively in low and high dose groups CONCLUSION Nitroglycerin patch appears to suppress uterine contraction in preterm labour, and may act as an effective, safe, well tolerated, and non invasive method for preterm labour

关 键 词：早产 硝酸甘油贴膜 促肾上腺皮质激素释放激素 分娩启动 

分 类 号：R714.21[医药卫生—妇产科学] R965[医药卫生—临床医学]