吡那地尔对培养大鼠交感神经元烟碱电流的影响  

Effect of pinacidil on nicotine-induced current in rat superior cervical ganglia

作　　者：万勤[1] 罗质璞[1] 汪海[1] 

机构地区：[1]军事医学科学院毒物药物研究所三室,北京100850

出　　处：《中国药理学通报》2002年第6期646-649,共4页Chinese Pharmacological Bulletin

摘　　要：目的　研究ATP敏感性K+ 通道 (KATP)开放剂吡那地尔对大鼠颈上交感神经元烟碱诱发电流的影响。方法　采用培养的交感神经元的全细胞膜片钳技术。结果　吡那地尔在较高浓度时 (10 0 μmol·L-1)对烟碱电流具有一定的抑制作用 ,但并不影响烟碱受体的失敏 ;KATP阻断剂格列苯脲不能对抗吡那地尔对烟碱电流的抑制效应。结论　吡那地尔对大鼠交感神经元烟碱电流具有一定的抑制作用 ,其作用并不通过KATP介导。AIM To study the effect of ATP sensitive potassium channel(K ATP ) opener pinacidil on the current induced by nicotine in cultured rat superior cervical ganglia. METHOD Whole cell patch clamp technique. RESULTS Pinacidil inhibited nicotine induced current when in higher dose(100 μmol·L -1 ), but had no effect on the desensitization of nicotinic receptors. K ATP antagonist glibenclamide didn't influence the inhibitory effect of pinacidil on nicotinic current. CONCLUSION Pinacidil had an inhibitory effect on nicotine induced current in rat superior cervical ganglia and this effect wasn't mediated by K ATP .

关 键 词：吡那地尔 烟碱电流 交感神经元 全细胞膜片钳技术 

分 类 号：R965[医药卫生—药理学]