血浆同型半胱氨酸与冠状动脉病变的关系  

The relationship between plasma homocysteine and coronaryartery stenosis.

作　　者：吴畅[1] 林云[1] 孙璟[1] 杜萱[1] 

机构地区：[1]上海市第二医科大学附属瑞金医院,200025

出　　处：《现代医药卫生》2003年第1期8-9,共2页Journal of Modern Medicine & Health

摘　　要：目的 :探讨血浆同型半胱氨酸 (Hcy)与冠状动脉病变及累及病变支数的关系。方法 :对121名行冠状动脉造影术的患者进行血浆Hcy、叶酸、维生素B12 的检测。其中冠心病组83人 ,非冠心病组38人 ,冠心病组又根据病变支数分为单支病变组 (25例 )、双支病变组 (35例 )、三支病变组 (23例 )。结果 :冠心病组的血浆Hcy水平为 (16 06±6 98) μmol/L ,明显高于非冠心病组(11 11±4 27) μmol/L ,P<0 001。冠心病组的单支、双支、三支病变组其血浆Hcy 均显著高于非冠心病组 ,但三者之间差异无显著性。结论 :血浆Hcy 增高是冠状动脉病变的独立危险因素 ,血浆Hcy 水平可能与累及冠状动脉支数无关。Objective:To study whether plasma homocysteine(Hcy) is an independent risk factor for coronary-artery stenosis in the elder,and the relationship between plasma homocysteine and the number of coronaryartery with stenosis.Methods:Plasma Hcy,folic acid and VitB12 were measured in 121 patients who underwent coronary angiography.In this group,83 patients were definded as having coronary heart disease(CHD),while the other 38 as the controls.CHD cases were divided into sigle-vessel(n=25),double-vessel(n=35) and triple-vessel group(n=23).Results:The plasma Hcy levels are significantly higher in the CHD patients than that in the controls(16.06±6.98 vs 11.11±4.27μmol/L;P<0.001).Althought the plasma Hcy levels in the three groups of sigle-vessel,doublevessel and triple-vessel show no significant difference,but they are all distinguishedly higher than the controls.Conclusion:Increased plasma homocysteine is an independent risk factor for coronary-artery stenosis,but may predit no significant relationship with the number of coronaryartery with stenosis.

关 键 词：同型半胱氨酸 冠心病 冠状动脉造影 

分 类 号：R541.4[医药卫生—心血管疾病]