针刺对不同性别单纯性肥胖大鼠Lee's指数与Leptin含量的影响  

Effect of Lose Weight on the Different Gender Rats with Simple Obesity by Acupuncture

作　　者：董乃相 张书义[1] 梁玉磊[2] 许晓康[2] 肖红玲[2] 孙永辉 孙立虹[2] 

机构地区：[1]北京市丰台社区卫生服务中心,北京100071 [2]河北中医学院,河北石家庄050200 [3]宁晋人民医院,河北宁晋055550

出　　处：《中医学报》2015年第6期846-848,共3页Acta Chinese Medicine

基　　金：河北省中医药管理局科学研究计划项目(2009006)

摘　　要：目的:比较针刺干预对不同性别单纯性肥胖大鼠Lee’s指数和血、脑瘦素(Leptin)含量的影响,探讨针刺塑形效果与性别的差异性及可能作用机制。方法:采用谷氨酸钠和高脂饮食诱导法制造下丘脑性肥胖大鼠模型,随机分为模型雌组、雄组,治疗雌组、雄组,另设正常雌组、雄组,每组8只大鼠。治疗组毫针刺曲池、中脘、关元、后三里、丰隆、三阴交穴,每日1次,连续治疗28 d。观察治疗前后雌、雄两组大鼠Lee’s指数和血清、下丘脑Leptin含量的变化,并进行统计比较。结果:与模型雌组、雄组比较,治疗雌组、雄组的Lee’s指数和血清、下丘脑Leptin的含量均明显改善(P<0.01),且治疗雄组优于治疗雌组(P<0.05)。结论:针刺对雌雄两性单纯性肥胖大鼠均可起到减肥作用,但在减肥塑形方面,对雄性的疗效优于雌性。Objective:To explore the effect of needle shape,gender differences and the possible mechanism of action by comparing Lee’s index and blood,brain leptin levels of acupuncture intervention on the different gender rats with simple obesity. Methods:Manufacturing hypothalamic obese rats model by using sodium glutamate and high-fat diet candidated,randomly divided into model female group,model male group and treatment female group,treatment male group,in addition normal female group,normal male group,8 rats or each group. The treatment group was proded by filiform needle in acupuncture with Quchi( LI11),Zhongwan( CV12),Guanyuan( CV4),Housanli( ST36),Fenglong( ST40),Sanyinjiao( SP6). 1 time a day. After the 28 days,explore the change of Lee’ s index and blood,brain leptin levels of the female and male group,and comparing the statisics. Results:Comparing with the model group,the Lee ’s index and blood,brain leptin levels improve( P < 0. 01) of the treatment group,and treatment female group is superior to the treatment male group. Conclusion:Acupuncture can lose weight for the both gender rats with simple obesity,but in terms of weight loss in shape,curative effect is better than that of female of male.

关 键 词：针刺 单纯性肥胖 Lee’s指数 瘦素 大鼠 

分 类 号：R245[医药卫生—针灸推拿学]