细胞粘附与树突状细胞迁移机制  

Cell adhesion and the mechanisms of dendritic cells immigration

作　　者：刘巍[1] 周同[1] 史浩[1] 孙桂芝[1] 陈楠[1] 张冬青[2] 

机构地区：[1]上海第二医科大学瑞金医院,上海200025 [2]上海第二医科大学上海市免疫学研究所,上海200025

出　　处：《生命科学》2002年第6期379-382,372,共5页Chinese Bulletin of Life Sciences

基　　金：国家自然科学基金(39970340);上海市自然科学基金(02ZB14041)

摘　　要：树突状细胞(dendritic cell,DC)是迄今已知功能最强的抗原递呈细胞。DC体内迁移机制与其分化成熟、表型转换及生物学功能发挥密切相关。粘附分子及其介导的细胞粘附参与了DC的迁移机制。深入研究DC迁移的分子基础,有助于进一步阐明DC的生物学特性和功能,也可为通过DC进行免疫调控用于临床疾病防治提供重要理论基础。Dendritic cells (DC) are known as the most strong antigen-presenting cells so far. While the mechanisms of DC immigration are association with its differentiation, immature and mature phenotypes, biological functions, adhesion molecules and its mediating cell adhesion involve the mechanisms of DC immigration. Investigation of the molecular bases of DC immigration will further elucidates DC biological characters and functions by which would perform immunoregula-tion and provide an important base for clinical therapies.

关 键 词：细胞粘附 树突状细胞 迁移机制 粘附分子 细胞迁移 

分 类 号：Q25[生物学—细胞生物学]