芜菁叶汁对环磷酰胺致小鼠突变的拮抗作用  

Antagonistic action of leaf juice of Brassica rapa on damaged mouse by cyclophospamide.

作　　者：钱晓薇[1] 孔小映[1] 许成武[1] 朱睦元[2] 朱小春[3] 

机构地区：[1]温州师范学院生物环境系,浙江温州325003 [2]浙江大学生命科学学院,浙江杭州325012 [3]温州医学院附属一医,浙江温州325003

出　　处：《浙江大学学报（理学版）》2003年第1期89-92,共4页Journal of Zhejiang University（Science Edition）

基　　金：温州市科委科研基金资助项目(N990313);温州师范学院科研基金资助项目(N2000Z012)

摘　　要：用清洁级ICR小鼠作动物整体试验,通过小鼠骨髓嗜多染红细胞(PCE)的微核试验、小鼠骨髓染色体畸变试验等方法.测定芜菁叶汁对环磷酰胺(Cyclophospamide,以下简称CP)引起遗传物质损伤的保护拮抗效应.灌胃(ig)不同剂量叶汁均使小鼠骨髓PCE微核率、骨髓染色体畸变率有所下降,且具有明显的剂量效应.芜菁叶汁对环磷酰胺引起小鼠的损伤具有明显的拮抗作用,提示芜菁叶汁具有一定的抗突变作用.To study the antagonistic action of Brassica rapa leaf juice on damaged mouse induced by cy-clophospamide (CP). the PCE micronucleus test and chromosomal aberration test were used. The dose of Brassica rapa leaf juice irrigated is significantly effective in reducing micronucleus rate of PCE and chromosomal aberration rate induced by CP in bone marrow of mice. The leaf juice of Brassica rapa has a remarkable antagonistic action on the injury induced by CP. So the leaf juice of Brassica rapa has an efficient antimutagenic action. The possible mechanism of antiradiation of leaf juice of Brassica rapa was also discussed.

关 键 词：芜菁叶汁 环磷酰胺 小鼠 拮抗作用 微核率 染色体畸变率 抗诱变作用 蔬菜 抗癌作用 

分 类 号：R282.71[医药卫生—中药学] R285.5[医药卫生—中医学]