应用系统全面反馈试验优化技术提高RGD短肽液相合成产率的初步研究  

Research of Using the Technology Optimizing Disposition of the System Factors with All over Feedback Control into Improving the Yield of the Peptide Synthesis

作　　者：邱凯[1] 万昌秀[1] 李天全[2] 陈馨[1] 张兴宇 

机构地区：[1]四川大学高分子材料与工程系,四川成都610065 [2]四川大学化工学院,四川成都610065 [3]四川高维系统工程技术有限公司,四川成都610016

出　　处：《科技通报》2003年第1期25-28,共4页Bulletin of Science and Technology

基　　金：国家自然科学基金资助项目(29874022)

摘　　要：多肽合成反应中,由于影响实验的因素较多,用传统的正交设计进行合成条件的优化难度太大,实验次数可能几十甚至上百次.本实验首次将系统全面反馈试验优化技术引入到多肽合成反应中,经试验证明该技术能快速找到最佳合成工艺的途径且能使接肽反应产率达到90%以上.In the reaction of peptide synthesis, it is very difficult to improve the yield of reactions by method of conventional orthogonal project because of its multitudinous factors and too many times of experiments. This is the first time to use the technology optimizing disposition of the system factors with all over feedback control into improving the yield of the peptide synthesis. It was proved that through this new kind of technology, the best route of synthesis can be found and the yield of peptide synthesis can be improved to more than 90 percent.

关 键 词：系统全面反馈试验优化技术 RGD短肽 液相合成 产率 多肽合成反应 优化设计 合成工艺 

分 类 号：TQ28[化学工程—有机化工]