Fe(Ⅲ)分光光度法测定盐酸氯丙嗪  

Determination of Chlorpromazine Hydrochloride by Spectrophotometry with Fe( Ⅲ )

作　　者：邹大喜 黄选忠[1] 

机构地区：[1]湖北省兴山县疾病预防控制中心,湖北兴山443711

出　　处：《化学分析计量》2015年第3期59-61,共3页Chemical Analysis And Meterage

摘　　要：建立了以Fe(Ⅲ)为氧化剂分光光度法测定盐酸氯丙嗪的方法。在盐酸介质中,Fe(Ⅲ)将盐酸氯丙嗪氧化形成一种红色化合物,该化合物的最大吸收波长位于525 nm,其摩尔吸光系数ε=1.05×104 L/(mol·cm)。盐酸氯丙嗪的质量浓度在0~20.0 mg/L范围内与体系的吸光度呈良好的线性关系,线性相关系数r=0.999 2,加标回收率为94.0%~100.4%,测定结果的相对标准偏差为0.55%~1.42%(n=6)。该法灵敏度较高、选择性及重现性良好,可用于药品和血清中盐酸氯丙嗪的测定。Spectrophotometry was established for the determination of chlorpromazine hydrochloride with Fe( Ⅲ) as oxidizing agent. In the medium of hydrochloric acid,chlorpromazine hydrochloride was oxidied by Fe( Ⅲ) to form a red compound,the maximum absorption wavelength of the compound was 525 nm,the molar absorptivity was 1.05×104 L/(mol · cm). The concentration of chlorpromazine hydrochloride was linear with absorbance in the range of 0–20.0 mg/L, and the correlation coeffi cient was 0.999 2. The recovery rate was 94.0%–100.4%,the relative standard deviation of detection results ranged from 0.55% to 1.42%(n=6). The method had high sensitivity,good selectivity and reproducibility,it can be used for the determination of chlorpromazine hydrochloride in drug and serum.

关 键 词：Fe(Ⅲ) 分光光度法 盐酸氯丙嗪 

分 类 号：R927.1[医药卫生—药学] O657.3[理学—分析化学]