呼气末二氧化碳分压监测在COPD中的应用  

Use of End-Tidal Carbon Dioxide Tension in Stable COPD Patients

作　　者：赵冰清[1] 陈宇清[2] 周新[2] 

机构地区：[1]上海市第一人民医院急诊科,200080 [2]上海市第一人民医院呼吸科

出　　处：《临床肺科杂志》2003年第1期1-3,共3页Journal of Clinical Pulmonary Medicine

摘　　要：目的　了解在稳定期慢性阻塞性肺疾病 (COPD)患者中测定呼气末二氧化碳分压监测 (Pet CO2 )与 Pa-CO2 的相关性及其与肺功能之间的关系。方法　采用前瞻性、对照研究方法。 4 5例受试者中 COPD患者 2 5例 ,年龄 6 9± 7岁 ;正常成年人 2 0例 ,年龄 6 5± 5岁。在测定肺功能后同时测定 Pet CO2 和 Pa CO2 。结果　COPD患者 Pa-CO2 显著高于正常组 ,两组患者 Pet CO2 比较无显著性差异 ,但均与 Pa CO2 显著相关 (r=0 .716和 0 .5 80 ,p<0 .0 1和 p<0 .0 5 )。 COPD组 ADco2 与肺功能各参数如 FEV1 、MMEF、s RAW和 PV/TL C显著相关 (p<0 .0 1)。结论　Pet CO2 可用于判断 Pa CO2 变化 ,ADco2 则可反映气流阻塞程度的严重程度 ,Pet CO2Objective To investigate the correlation between end tidal carbon dioxide tension (PetCO2) and PaCO2 in patients with chronic obstructive pulmonary disease (COPD). Methods Twenty five stable COPD patients (mean age 69+7 years) and 20 normal adults (mean age 65+5 years) took pulmonary function tests. Arterial blood gas (ABG) and PetCO2 were also measured.Results The value of PaCO2 in COPD group was significantly higher than that of the normal group. There was no significant difference between the two groups in terms of PetCO2. PetCO2 were significantly correlated with PaCO2 in both groups (r=0.716 and 0.58 for COPD and normal groups respectively; p<0.01 and p< 0.05 for the two groups respectively). ADco2 in COPD group was significantly associated with FEV1, MMEF, SRAW and RV/TLC (p < 0.01). Conclusion PetCo2 may reflect the change of PaCO2. Adco2 may be associated with airflow obstruction. PetCO2 is a useful non invasive index.

关 键 词：呼气末二氧化碳分压 慢性阻塞性肺疾病 肺功能 

分 类 号：R563.9[医药卫生—呼吸系统]