Ventricular remodeling by Scutellarein treatment in spontaneously hypertensive rats  

灯盏花对自发性高血压大鼠心室重构的药物干预研究

作　　者：周建中[1] 雷寒[1] 陈运贞[1] 李法琦[1] 马长生[2] 

机构地区：[1]重庆医科大学附属第一医院心血管内科,重庆400016 [2]北京中日友好医院,北京100029

出　　处：《Chinese Medical Journal》2002年第3期375-377,共3页中华医学杂志（英文版）

摘　　要：OBJECTIVE: To observe reversal of ventricular remodeling by the protein kinase C inhibitor Scutellarein in spontaneously hypertensive rats (SHRs). METHODS: Twelve SHRs were randomly divided into two groups. Scutellarein and saline (10 mg x kg(-1) x d(-1)) were given by intraperitoneal injection to two groups of rats separately. Systolic blood pressure (SBP) and ventricular weight index (LVW/BW, RVW/BW) were measured. A polarization microscope and an image analyzer system (IAS) were used to observe changes in cardiovascular structure and to count the content of cardiac muscle interstitial collagen. RESULTS: The pathologic changes in the left ventricle in the Scutellarein group rats (SHR(D)) improved to varying degrees, including hypertrophy of the cardiac muscle and collagen volume fraction. CONCLUSION: Scutellarein can reverse ventricular remodeling, improve myocardial stiffness and protect heart cardiac muscle.目的　观察蛋白激酶C抑制剂—灯盏花对SHR心脏血管重构逆转作用。方法　将 10月龄 12只SHR(SHR10 )随机分为 :灯盏花 (SHRD)、和生理盐水组 (SHRc) ,均以 10mg·kg 1·d 1腹腔内射给药 8周。测定血压、心室重量指数 ,偏振光镜、透射电镜观察心脏、血管结构改变。图象分析计算心肌间质胶原面积、含量。结果　灯盏花组左心室肥厚不同程度消退 ,明显改善心肌细胞肥大、变性 ,胶原容积分数 (CVF)降低 (P <0 0 5 )。结论　灯盏花可逆转心室重构 ,改善心肌僵硬度 ,具有心脏保护作用。

关 键 词：FLAVANONES ANIMALS Female FLAVONOIDS Hypertension Male Protective Agents Protein Kinase C Random Allocation RATS Rats  Inbred SHR Ventricular Remodeling 

分 类 号：R544.1[医药卫生—心血管疾病]