雷贝拉唑钠对幽门螺杆菌的体外抑菌效果观察  

In- Vitro Activity of Rabeprazole (Bolite) against Helicobacter pylori

作　　者：何利华[1] 尹焱[1] 尤元海[1] 闫笑梅[1] 张建中[1] 

机构地区：[1]中国疾病预防控制中心传染病预防控制所,北京昌平102206

出　　处：《疾病监测》2002年第12期452-454,共3页Disease Surveillance

摘　　要：目的观察质子泵抑制剂雷贝拉唑钠对幽门螺杆菌的抑制作用。方法应用平板掺入法研究雷贝拉唑钠(波利特)对幽门螺杆菌的体外抑菌作用。结果 发现雷贝拉唑钠在体外对幽门螺杆菌具有明显的抑菌作用(MIC99为2.25μg/ml),其体外抑菌作用强于奥美拉唑(洛赛克)。结论本研究结果提示雷贝拉唑钠对幽门螺杆菌的直接抑菌作用可能在幽门螺杆菌感染的治疗中有重要作用。Objective Rabeprazole is a gastric parietal. cell proton pump inhibitor, the aim of this study was to investigate its activity against Helicobacter pylori in vitro. Method We investigated its and imicrobial effect by deter- mining the MICs for 3H. pylori strains isolated from different ountries. Results The MIC99 was 2.25μg/ml for all the 3 strains, exhibiting a stronger inhibitory activity in vitro than Omeprazole. Conclusion It suggested that Rebaprazole contributed in the treatment of H. pylori infection not only for its anti - secretion of acid but also for its anti H. plori activity.

关 键 词：体外抑菌效果 质子泵抑制剂 幽门螺杆菌 雷贝拉唑 消化道溃疡 

分 类 号：R965[医药卫生—药理学]