氯解磷定对水胺硫磷中毒大鼠的神经肌肉传导作用  

The neuromuscular transmission effects induced by pralidoxime chloride on rats with acute isocarbophos poisoning

作　　者：琚志昌[1] 孙金秀[1] 

机构地区：[1]北京市疾病预防控制中心营养与食品卫生所微生物室,100013

出　　处：《中华劳动卫生职业病杂志》2002年第6期425-426,共2页Chinese Journal of Industrial Hygiene and Occupational Diseases

基　　金："十五"国家科技攻关课题 ( 2 0 0 1BA70 4B0 6 )

摘　　要：目的　探讨肟类药物在急性水胺硫磷中毒治疗中改善神经肌肉传导“非乙酰胆碱酯酶(AChE)重活化效应”的作用。方法　应用电刺激单纤维肌电图 (SSFEMG)研究氯解磷定 (PAM Cl)对水胺硫磷中毒大鼠神经肌肉传导的影响。结果　水胺硫磷中毒大鼠在给予PAM Cl治疗后 ,腓肠肌的单纤维动作电位平均连续差 (MCD)值为 (2 5 .99± 5 .84) μs,低于治疗前MCD值 [(33 .2 1± 4 .0 9) μs] ,差异有显著性 (P <0 .0 1 ) ;而全血和腓肠肌AChE活力并未见明显恢复。结论　PAM Cl有“非AChE重活化效应” ,可明显改善水胺硫磷中毒大鼠的腓肠肌神经肌肉传导 (NMT)Objective To study the effects of improving the neuromuscular transmission(NMT),'non AChE reactivating effects',by oximes in treating acute isocarbophos poisoning. Methods The effect of pralidoxime chloride(PAM Cl) on the neuromuscular transmission(NMT) in rats exposed to isocarbophos was studied by using the stimulation single fiber electromyography(SSFEMG) to determine the single fiber action potential. Results After the rats exposed to isocarbophos were treated by PAM Cl,the mean consecutive difference(MCD) value [(25.99±5.84)μs]of single fiber action potential was significantly lower than that before PAM Cl treatment [(33.21± 4.09)μs,( P <0.01)],but no AChE reactivation in blood and gastrocnemius was observed. Conclusion PAM Cl has 'non AChE reactivating effects',it could markedly improve isocarbophos induced NMT block of gastrocnemius.

关 键 词：大鼠 解磷定化合物 杀虫药 有机磷 神经传导 农药中毒 

分 类 号：R595.4[医药卫生—内科学]