探讨维持扩张期对扩张皮肤生物力学与胶原结构的影响  

Changes of biomechanical properties and collages of expansive skin in different maintenance and expansion periods.

作　　者：刘学军[1] 孙广慈[1] 管正玉[1] 何祯平[1] 杨欣[1] 

机构地区：[1]北京大学深圳医院整形外科,深圳518036

出　　处：《中华医学美学美容杂志》2002年第6期300-304,共5页Chinese Journal of Medical Aesthetics and Cosmetology

摘　　要：目的　以生物力学的方法探讨一种有效的缩短皮肤扩张时间的途径。方法　在 6只成年大狗的背侧 ,对称设计 6个术区 ,实验分为空白对照组、埋置扩张器不施行注水的对照组、注水 2周和注水 6周组 ,注水 2周组和注水 6周组又分为维持 1周、2周和 4周 3组。每个术区取 4个皮肤试件 ,分别测定极限应力强度、应力应变、应力松弛和蠕变 ,并测量单位面积的胶原含量和排列。结果　皮肤扩张后 ,极限应力强度下降 ;随着维持期的增加 ,应力应变、应力松弛和蠕变均逐渐接近正常 ,胶原含量增加 ,排列更加有序。结论　维持期对扩张皮肤的黏弹性和胶原的含量及其排列的恢复是不可少或缺的阶段 。Objective The study was to investigate a new method of rapid expansion by biomechanical methods. Methods Dogs were set up as animal models. Six areas, 5 cm×8 cm each, were symmetrically designed on a dog. Expanders of 240 ml were implanted in each area. Four groups were divided: A. Injection of 2 weeks. B. Injection of 6 weeks. C. Sham operation group. D. Blank control group. The first two groups were subdivided into three groups respectively according to maintaining times: one week, two weeks and four weeks. The following indexes were measured on the second stage surgery: biomechanical properties of the skin, stress strength, stress strain, stress relaxation and creep, the collagen content and alignment of skin. Results After expansion, maximal stress strength fell off, and stress strain curve moved backward. Relaxation curve fell off as well, as creep curve rose up. With elongation of the maintaining period, viscoelasticity of the skin gradually approximated normal skin, and had less relation with injection time. With the maintaining period increased, the collage content increased distinctly, and the alignment became much order. Conclusion Two week maintaining period is very important for expanded skin to recover the biomechanical properties and the content of collagen and alignment.

关 键 词：扩张期 皮肤扩张术 生物力学 胶原 整形外科 

分 类 号：R628[医药卫生—整形外科]