Na^+-H^+交换抑制剂在心肌缺血与再灌注损伤中的研究进展  

Research Progress on Na^+-H^+ Exchanger Inhibitor in Myocardial Ishemia-Reperfusion Injury

作　　者：姚道阔[1] 

机构地区：[1]泰山医学院附属医院心内科,山东泰安271000

出　　处：《现代诊断与治疗》2003年第1期37-39,共3页Modern Diagnosis and Treatment

摘　　要：抑制肌膜Na+ H+ 交换能减少心肌缺血与再灌注损伤。动物实验显示 ,Na+ H+ 交换抑制剂能减少心肌缺血与再灌注时的严重心律失常发生率 ,延缓心功能不全的发生 ,限制组织坏死。临床试验显示 ,Na+ H+ 交换抑制剂可减少心肌梗死后再灌注损伤 。The inhibition of Na +/H + exchange in cardiac cell membrane could reduce myocardial injury following ischemia reperfusion.Experiments in animals show that Na +/H + exchanger inhibitors could reduce the rates of severe arrhythmias induced by ischemia reperfusion,attenuate the onset of cardiac dysfunction,and control the tissue necrosis.Clinical experiments show that Na +/H + exchanger inhibitors could reduce reperfusion injury after myocardial infarction,and improve the recovery of left ventricular dysfunction.

关 键 词：心肌缺血 再灌注损伤 研究进展 Na^+-H^+交换抑制剂 

分 类 号：R542.22[医药卫生—心血管疾病]