妊娠反应与孕早期碘营养和垂体-甲状腺功能的关系  

Relation between morning sickness and iodine nutrition,pituitary-thyroid function during early pregnant stage

作　　者：李思果[1] 彭良斌[1] 黄薇[2] 王继尧[2] 魏若飞[2] 

机构地区：[1]华中科技大学同济医学院 [2]深圳市疾病预防控制中心,518020

出　　处：《中国公共卫生》2003年第1期37-38,共2页Chinese Journal of Public Health

基　　金：深圳市科技计划经济资助课题 (2 0 0 2 0 4 1 2 7)

摘　　要：目的　揭示妊娠反应对垂体 -甲状腺功能的影响。方法　收集在市妇幼医院确诊的第 12～ 14周孕早期及同龄婚检妇女血及尿。血碘采用改进的砷铈催化分光光度法 ,FT4 、FrT3、sTSH用化学发光法测定 ,妊娠反应采用评分量化。结果　 47例妊娠反应阳性的血清碘 (G) 61 2 μg/L ,尿碘 (G) 15 2 1μg/L ,FT4 为 14 42pmol/L ,FrT3/FT4 为0 3 46,sTSH为 3 78mU/L ,分别低于和高于妊娠反应阴性组和未孕组 (P均 <0 0 1) ,阳性组尿碘 <10 0 μg/L有 2 0 %及sTSH >5 0mU/L有 8 6%。除未孕组FT4 与FrT3无相关性外 ,余下妊娠反应阳性程度与血清碘和FT4 及sTSH均有密切相关 (r=0 65 4和r=- 0 3 5 4,P <0 0 1及P <0 0 5 )。结论　妊娠反应对孕早期碘营养代谢、垂体 -甲状腺功能减弱有协同作用 。Objective In order to reveal the effects of morning sickness on pituitary-thyroid function.Methods To collect urine and vein blood of early pregnant women(12-14 weeks) and marriage examination women in the Women and Children Hospital of Shenzhen.Iodine in urine was determined by As(Ⅲ)-Ce 4+ catalytic spectrophotometry to measure serum iodine,Automated Chemiluminescence System was used to test FT 4?FrT 3 and sTSH.Results Serum iodine(G) of 35 pregnant women who had morning sickness was 61.2?μg/L,urine iodine was 152.1?μg/L,FT 4 was 14.42?pmol/L,FrT 3/FT 4 WAS 0.346,sTSH was 3.78?mU/L.All of them were obviously lower or higher than those of non-morning sickness and non-pregnant group( p <0 01).Urine iodine of morning sickness group <100?μg/L was 20%,and sTSH>5 0?mU/L was 8.6%.Correlation was found between serum iodine and FT 4,sTSH in morning sickness group except for non-pregnant group( r =0 654 and -0 354, P <0 01 and P <0 05).Conclusion Coordination impact was found between metabolism of iodine nutrition and descent of pituitary-thyroid function during early pregnancy,which should be paid attention to.

关 键 词：孕早期 妊娠反应 垂体-甲状腺功能 相关性 

分 类 号：R714[医药卫生—妇产科学]