N和M胆碱能受体之间的相互调节  

Interactions of nicotinic and muscarinic acetylcholine receptors

作　　者：万勤[1] 罗质璞[1] 汪海[1] 

机构地区：[1]军事医学科学院毒物药物研究所,北京100850

出　　处：《中国药理学通报》2003年第1期17-20,共4页Chinese Pharmacological Bulletin

摘　　要：N和M胆碱能受体拥有同一种内源性配基ACh ,并且在多种组织中两种受体共存 ,两者之间存在着多种相互作用。如副交感神经节后N受体可通过刺激胆碱能神经纤维末梢释放ACh来调节组织中M受体的功能 ;而胆碱能神经元突触后N受体的活性也可被突触前膜上M和N的自受体通过反馈调控节前纤维ACh的释放来调节 ;另外 ,N受体被阻断或失敏后不同组织中M受体的功能会发生不同的变化 。Nicotinic and muscarinic acetylcholine receptors have the same endogenous ligand ACh and are distributed together in many tissues, so it is reasonable to believe that there must be some interactions existed between them. The functions of muscarinic receptors in the tissues innervated by the parasympathetic cholinergic postfibers, can be modulated by the ganglionic nicotinic receptors through stimulating ACh release. In ganglia, the postsynaptic nicotinic receptor activities can be modulated by the presynaptic muscarinic and nicotinic autoreceptors through regulating ACh release. Moreover, The functions of muscarinic receptors can be changed by nicotinic receptor desensitization or blockade. The two types of receptor act on each other and keep in a varied homeostasis of cholinergic nervous system.

关 键 词：胆碱能受体 N受体 M受体 突触前机制 失敏 

分 类 号：R392.11[医药卫生—免疫学] R322.85[医药卫生—基础医学]