HLA-DRB1、DQA1、DQB1基因与上海地区类天疱疮的易感性  

Molecular Analysis of HLA-DRB1,DQA1,DQB1 in Patients with Bullous Pemphigoid

作　　者：金岩[1] 黄懿[2] 翁孟武[1] 

机构地区：[1]复旦大学附属华山医院皮肤科,上海200040 [2]上海市东方医院皮肤科,上海200120

出　　处：《复旦学报（医学版）》2003年第1期20-23,共4页Fudan University Journal of Medical Sciences

摘　　要：目的　为探讨HLA Ⅱ类基因与类天疱疮 (BP)的相关性 ,了解BP的免疫遗传发病背景。方法　采用PCR SSOP方法对上海地区汉族 5 6例BP患者和 15 0例健康对照者进行了HLA DRB1、DQA1、DQB1位点等位基因分型。结果　发现HLA DRB1 10 0 1与DQB1 0 5 0 1紧密连锁 ,其基因频率BP组与对照组比较明显增高 ;DRB1 0 4与DQB1 0 3 0 2紧密连锁 ,其基因频率与对照组比较也明显增高 ;DRB1 12基因频率BP组与对照组比较明显降低 (P =0 .0 0 7,RR =0 .3 5 8)。结论　DRB1 10 0 1、DRB1 0 4可能为上海地区BP患者的易感基因 ,而DRB1 12 ( 12 0 1, 12 0 2 )Purpose: To investigate the association between Bullous pemphigus (BP) and HLA class II genes. Methods: Fifty six cases of BP patients and 150 normal individuals in Shanghai area were genotyped for DRB1, DQA1, DQB1 locus by PCR-SSOP method. Results: HLA-DRB1*10 (*1001) linked with DQB1*0501,DRB1*04 linked with DQB1*0302, frequencies of these two alleles were significantly increased in BP group compared with normal control; DRB1*12(*1201, *1202) decreased in BP group compared with normal control. Conclusions: It is suggested that HLA-DRB1 *1001, DRB1*04 may be the susceptible gene and DRB1*1201, *1202 may be the protective genes of BP patients in Shanghai area.

关 键 词：HLA-DRB1 DQA1 DQB1 易感性 类天疱疮 免疫遗传学 PCR-SSOP 

分 类 号：R758.66[医药卫生—皮肤病学与性病学]