Taq Man技术在原发性高血压候选基因ACE多态位点分型上的应用  

Genotyping of Essential Hypertension Candidate Gene-ACE by TaqMan

作　　者：卫灿东[1] 柯玉雄[1] 金建中[1] 金力[1] 

机构地区：[1]复旦大学生命科学学院遗传学研究所,现代人类学研究中心,上海200433

出　　处：《复旦学报（自然科学版）》2002年第6期614-617,共4页Journal of Fudan University：Natural Science

基　　金：国家"973"基金资助项目(G199805014)

摘　　要：利用TaqMan技术对原发性高血压候选基因———ACE基因4504位的G/C多态进行大样本分型,结果发现C等位基因与高血压有显著相关性(P<0.05).提示ACE基因和原发性高血压的发生有着密切关系.同时摸索建立一高通量SNP分型的操作平台.One SNP (4504, G/C) of ACE gene was genotyped by TaqMan in large samples (about 800), found that C allele has significant correlation with the essential hypertension (P<0.05), which may imply ACE gene is one of candidate genes of essential hypertension. At the same time, one highthroughput platform about SNP genotyping by TaqMan was set up.

关 键 词：单核苷酸多态性 TAQMAN技术 原发性高血压 血管紧张素转换酶 

分 类 号：R544.1[医药卫生—心血管疾病]