巴曲酶对NJS小鼠短暂性脑缺血发作后神经细胞的保护和改善认知功能的作用  

Protection of the neurons and improvement of the cognitive function after transient global forebrain ischemia attack in NJS mice used batroxobin

作　　者：高志强[1] 

机构地区：[1]南京军区南京总医院神经内科,210002

出　　处：《临床神经病学杂志》2002年第5期287-289,共3页Journal of Clinical Neurology

摘　　要：目的　观察巴曲酶对小鼠短暂性脑缺血发作 (TIA)后神经细胞的保护和改善认知功能的作用。方法　选择自发性高胆固醇血症小鼠 5 6只 ,分为对照组 (缺血发作但未用药 )、缺血前 2小时用药组、缺血后 2小时用药组、缺血后 2 4小时用药组。缺血后 72小时测定各组小鼠的认知行为学指标和海马CA1区神经元凋亡数。结果　缺血前 2小时用药组和缺血后 2小时用药组神经元凋亡数较对照组少 ,认知功能恢复好于对照组。缺血后 2 4小时用药组各项指标与对照组相比无统计学差异。结论　巴曲酶对小鼠TIA后神经元有保护作用和促进认知功能恢复 。Objective To observe protection of the neurons and improvement of the cognitive function after transient global forebrain ischemia attack(TIA) in NJS mice used batroxobin.Methods 56 NJS mice were divided into four groups: control group (ischemia attack group, but no using batroxobin), batroxobin group used 2 hours before ischemia attack, batroxobin group used 2 hours after ischemia attack and batroxobin used 24 hours after ischemia attack. The scores of cognitive behavior and the numbers of neuron apoptosis in CA 1 of hippocampus were estimated 72 hours after ischemia attack.Results The numbers of neuron apoptosis were fewer and the cognitive function was better in the group used batroxobin 2 hours before and after ischemia attack; the scores of the scales in the group used batroxobin 24 hours after ischemia were not different as compared with the control group.Conclusion Batroxobin can reduce the numbers of neuron apoptosis and promote the recovery of congnitive function in NJS mouse after TIA,but it should be used in the early stage after TIA.

关 键 词：脑缺血 巴曲酶 细胞凋亡 认知功能 

分 类 号：R965[医药卫生—药理学]