雄性生殖道巨噬细胞研究进展  

Progresses on Macrophages of Male Reproductive Tract

作　　者：李菁菁[1] 

机构地区：[1]河北医科大学组织学与胚胎学教研室,河北石家庄050017

出　　处：《中华男科学杂志》2002年第6期449-451,共3页National Journal of Andrology

摘　　要：综述了近年来关于雄性生殖道内巨噬细胞的研究进展 ,及其在男性生殖生理及病理方面的作用 ,包括睾丸巨噬细胞与Leydig细胞、支持细胞、生精细胞及下丘脑 垂体 性腺轴的紧密联系和相互影响 ,巨噬细胞在免疫炎症中的形态和功能改变 ,以及对炎症进展的调节作用。从而进一步阐明了睾丸巨噬细胞在睾丸内复杂的免疫调节网络中起的重要作用及其在生精过程和睾丸生精微环境的稳定中所发挥的独特功能 。The review summarized the recent progress on macrophages of male reproductive tract and the action of macrophages on male reproductive physiology and pathology. The close correlation and effect between testicular macrophages and Leydig cells, Sertoli cells, germ cells, hypothalamic pituitary gonadal axis were introduced, respectively. At the same time, it pointed out the changes of macrophages' morphology and function in immune orchitis, and their regulation on the development of orchitis. So the complex immune regulation network in testes and testicular macrophages playing an important role on spermatogenesis and the stableness of spermatogenetic microenvironment in testes were further illuminated, which can provide theoretical basis for clinic therapy.

关 键 词：巨噬细胞 生殖生理 生殖病理 免疫调节网络 

分 类 号：R392[医药卫生—免疫学]