温州地区广州管圆线虫病的研究  

Study on Angiostrongyliasis cantonensis in Wenzhou

作　　者：潘长旺[1] 梁韶晖[1] 黄慧聪[1] 凌洪博[1] 刘启真[1] 郑晓云[1] 秦茜[1] 金永国[1] 易维平 林宝楚 周仲良 王克华 凌大雄 

机构地区：[1]温州医学院,浙江温州325027 [2]温州市疾控中心,浙江温州325000

出　　处：《温州医学院学报》2002年第6期341-343,共3页Journal of Wenzhou Medical College

摘　　要：目的 :阐明温州地区 1997年 10～ 11月暴发流行“酸脑”的病因 ,并为该病的防治提供科学依据。方法 :分析患者发病过程及临床症状 ,针对性开展温州地区广州管圆线虫病流行学调查 ,同时用免疫学试验作临床辅助诊断。结果 :温州存在广州管圆线虫的自然疫源地 ,主要中间宿主 (福寿螺 )及终末宿主的感染率分别为 6 9.4 %和 19.5 % ;患者皮内试验及间接荧光抗体试验阳性率分别为 10 0 %和 90 .6 % ,ELISA法用于检测广州管圆线虫血清具有较高的敏感性和特异性。结论 :确定温州地区此次爆发流行的“酸脑”为广州管圆线虫病 ,温州地区为广州管圆线虫病流行区。Objective:To expound the cause of epidemic eosimophilic meningitis that was epidemic in Wenzhou from Oct. to Nov. 1997 and to provide the scientific basis for its prevention and treatment.Methods:Elementary studies on the epidemiology and immune diagnosis of Angiostrongyliasis cantonensis were carried out.Results:There exist the focus infectivities of Angiostrongylus cantonensis in Wenzhou. The infection rate of intermediate host (Ampullaria gigas) and final host were 69.4% and 19.5%. 32 patients with eosimophilic meningitis were detected by intradermal test and indirect fluorescent antibody test,the positive rate was 100% and 90.6% respectively.ELISA has a high sensitivity and specificity in defecting serum antibodies in infected rats.Conclusion:Epidemic eosimophilic meningitis that appeared in Wenzhou was caused by Angiostrongylus cantonensis.Wenzhou is the epidemic are of Angiostrongyliasis cantonensis.

关 键 词：温州市 广州管圆线虫 流行病学研究 

分 类 号：R532.1[医药卫生—内科学]