尿β_2—m、Alb、IgG对糖尿病肾病早期诊断的价值  

Value of β_2-m、Alb and IgG in urine in early diagnosis of diabetic nephropathy

作　　者：于璟[1] 王善菊[1] 曹慧玲[1] 

机构地区：[1]大连医科大学第二临床学院核医学科,辽宁大连116027

出　　处：《大连医科大学学报》2002年第4期256-258,共3页Journal of Dalian Medical University

摘　　要：[目的 ]探讨尿 β2 —m、Alb、IgG对糖尿病肾病早期诊断的价值。 [方法 ]采用放射免疫分析法检测 39例正常人及 72例糖尿病患者尿 β2 —m、Alb、IgG的质量浓度 ,并与血BUN、Cr等指标比较。[结果 ]糖尿病组尿 β2 —m、Alb、IgG的质量浓度量分别为 (332 .76± 98.4 2 )ng/mL、(2 7.37±10 .6 4)、(8.5 7± 3.0 4 ) μg/mL ,明显高于对照组 (P值分别为 <0 .0 0 1,<0 .0 0 1,<0 .0 1) ,其阳性率均高于常规评价肾功能的指标如BUN、Cr等 (与Cr比较 ,p值分别为 <0 .0 5 ,<0 .0 1,<0 .0 5 )。在尿Alb阴性者中 ,有 14例 β2 —m阳性。[结论 ]尿微量蛋白 β2 -m与Alb的联合检测有助于糖尿病肾病的早期诊断。To explore the value of β 2-m?Alb and IgG of urine in the early diagnosis of diabetic nephropathy . The authors measured the urine level of β 2-m?Alb and IgG in 39 normal cases and 72 patients with DN, and compared them with BUN and Cr in serum. The β 2-m?Alb and IgG level of patients with DN are (332.76±98.42) ng/mL?(27.37±10.64) μg/mL and (8.57±3.04) μg/mL respectively, and higher than those in normal cases remarkably (the P value is <0.001,<0.001,<0.01 respectively) , the rate of patients whose urine level is positive are higher than BUN and Cr (the P value is <0.05,<0.01,<0.05 respectively). The β 2-m levels are higher abnormally in 14 patients whose Alb level is negative . [Conclusion] The detection of urine β 2-m?Alb and IgG are valuable in the early diagnosis of DN; the combined use of these three indexes can elevate the positive rate of DN diagnosis.

关 键 词：糖尿病肾病 尿微量蛋白 放射免疫 

分 类 号：R587.2[医药卫生—内分泌] R692[医药卫生—内科学]