畸变产物耳声发射应用于高危新生儿听力筛查  

Application of Distortion Product Otoacoustic Emissions to High Risk Neonates' Hearing Screening

作　　者：张峥[1] 夏正毅[2] 迟放鲁[3] 

机构地区：[1]复旦大学附属儿科医院耳鼻喉科,研究生200032 [2]上海市松江区中心医院耳鼻喉科 [3]复旦大学附属眼耳鼻喉科医院耳鼻喉科,200031

出　　处：《中国眼耳鼻喉科杂志》2003年第1期5-7,共3页Chinese Journal of Ophthalmology and Otorhinolaryngology

摘　　要：目的探讨畸变产物耳声发射应用于高危新生儿听力筛查的可行性及临床意义。方法对904例高危新生儿及100例正常新生儿在出生后进行畸变产物耳声发射(DPOAE),对未通过的新生儿3个月后复查DPOAE及听性脑干反应随访。结果初查时,正常新生儿和高危新生儿DPOAE通过率为99%和66.59%,复查时高危新生儿的DPOAE通过率为83.92%。有8例复查时仍未通过者进行听性脑干反应,确诊为听力损害。结论 DPOAE是一种快速、敏感、无创、简便易行的听力筛查方法,可作为高危新生儿听力筛查的基本方法。听力损害家族史、高胆红素血症及窒息是引起新生儿听力损害的常见高危原因;听力损害家族史是其中最主要的原因。Purpose To investigate the feasibility and clinical significance of hearing screening with distortion product otoacoustic emissions (DPOAE) on high risk neonates. Methods Nine hundred and four cases of high risk neonates and 100 healthy newboms were tested with DPOAE 2 times (i.e. , before their discharge from hospital and 3 months later). Those who failed in 2 tests with DPOAE were tested with acoustic brain-stem response (ABR). The results were compared with those of 100 healthy neonates using prospective cohort. Results The presence of DPOAE in high risk neonates was 66. 59% in the first test, while in healthy neonates was 99% . In the second 3 months later, the presence of DPOAE in high risk neonates was 83.92% . 8 of 44 high risk neonates' who failed in DPOAE test were confirmed by ABR test. Conclusion The DPOAE test has been found to be practical and quick enough to be performed in high risk neonates. Hearing loss family history, hyperbilirubinemia and asphyxia are the frequent high risk factors of neonates' hearing loss; Hearing loss family history is the most frequent high risk factors of the three.

关 键 词：畸变产物 耳声发射 高危新生儿 听力筛查 

分 类 号：R764[医药卫生—耳鼻咽喉科]