磷脂酶A_2在腰椎间盘突出症髓核中的表达及相关临床研究  

Expression and associative clinical study of phospholipase A_2 in the nuclei pulposus of herniated lumbar discs

作　　者：张文煜[1] 郑祖根 高铁民[1] 徐道堃[1] 徐圣华[1] 陈登有[1] 

机构地区：[1]南京医科大学附属苏州医院 [2]苏州大学附属第二医院骨科,江苏苏州215004

出　　处：《颈腰痛杂志》2003年第1期11-14,共4页The Journal of Cervicodynia and Lumbodynia

摘　　要：目的　探讨磷脂酶 A2 (PL A2 )在腰椎间盘突出症中的作用机制。方法　 1.在术前和术中收集 35例因腰椎间盘突出而手术的病人的疼痛程度、直腿抬高试验度数、突出病理征象等临床资料 ,采集突出组和对照组 (8例 )的血清和髓核标本。2 .应用微孔比色法测定 PL A2 的活性。 3.将获得的数据和临床资料进行统计学分析。结果　突出组髓核中的 PL A2 活性高于对照组 ,血清中两组无差异。髓核 PL A2 活性在破裂型或游离型中同在凸起型中的表达有差异 (P <0 .0 5 ) ,与直腿抬高试验度数呈负相关 (r=- 0 .344 ) ,与疼痛存在相关性 (P <0 .0 5 )。结论　腰椎间盘突出症髓核的 PL A2 活性高于正常腰椎间盘 ,化学性炎症机制在腰椎间盘突出症根性疼痛中发挥着可能比机械压迫更重要、更直接的作用 ,PL A2Objective To explore the functional mechanism of phospholipase A 2(PLA 2) in the nuclei pulposus(NP) of herniated lumbar discs Methods To collect the clinical materials-grades of pain, degrees of straight leg raising(DSLR), protrudent pathology and so on, of 35 operated patients of herniated lumbar discs (herniated groups), and the samples of serums and pulposus of the herniated and control groups in the preoperation and operation To assay PLA 2 and to perform statistical analysis Results The activities of PLA2 in NP of the herniated groups are over the control groups ,but these in serum aren't different The activities of PLA 2 are variant in the projecting types and negative correlation with DSLR, as well as, correlation with the grades of pain Conclusion The activities of PLA 2 in herniated discs are very much more than these in normal discs Chemical inflammatory mechanisms may play more important and direct role than mechanical compression in sciatica of herniated lumbar discs and inhibitors of PLA 2 will come to a new medicament for treating herniated lumbar discs

关 键 词：磷脂酶A2 腰椎间盘突出症 髓核 临床研究 

分 类 号：R681.53[医药卫生—骨科学] Q556[医药卫生—外科学]