肉苁蓉总苷对家兔失血性休克/再灌注损伤的治疗效应  

THE THERAPEUTIC EFFECTS OF GLYCOSIDES OF CISTANCHE ON HEMORRHAGIC SHOCK/REPERFUSION INJURY IN ANIMAL EXPERIMENT

作　　者：梁明华[1] 孙沛毅[1] 杨晓梅[1] 周杰[1] 

机构地区：[1]江苏省扬州大学医学院,江苏扬州225001

出　　处：《江苏临床医学杂志》2002年第6期516-517,共2页Journal of Jiangsu Clinical Medicine

摘　　要：目的 :研究肉苁蓉总苷 (glycosidesofcistanche ,GC)对家兔失血性休克 /再灌注 (hemorrhagicshock/reperfusion ,S/R)损伤的治疗作用。方法 :应用家兔S/R模型 ,观察血浆中过氧化脂质 (LPO)含量、丙二醛 (MDA)含量、超氧化物歧化酶(SOD)活性和血栓素A2 (TXA2 )、前列环素 (PGI2 )代谢产物的浓度以及GC对上述指标的影响。结果 :与假手术组比较 ,S/R组LPO、MDA、TXB2 明显升高 ,SOD、6-酮 -PGF1α明显降低 ,GC可逆转上述指标的变化。结论 :GC对S/R损伤有治疗作用。Objective:To study the therapeutic effects of glycosides of cistanche on hemorrhagic shock/reperfusion injury(S/R).Methods:Changes of several parameters and effects of GC on it were observed with hemorrhagic shock/reperfusion injury (S/R) rabbit model, parameters of which included LPO,MDA,SOD,TXB 2 and 6-keto-PGF1.Results:LPO,MDA and TXB 2 increased significantly(P<0 01),SOD and 6-keto-PGF1α decreased significantly(P<0 01) in S/R group compared with sham group.With treatment of GC,the abnormal changes of all above parameters were diminished remarkably(P<0 05 and P<0 01).Conclusion:GC hasa therapeutic effect on hemorrhagic shock/reperfusion injury.

关 键 词：肉苁蓉总苷 休克 缺血再灌注损伤 中药 药理 治疗效应 

分 类 号：R285.5[医药卫生—中药学]